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Understanding Heart Failure in Patients with Dilated Cardiomyopathy: A Direct Tissue Analysis from Explanted Human Hearts
DownloadFall 2022
Background Chronic heart failure (HF) remains a rising global epidemic that affects both adults and children population. The causes of HF are heterogeneous, and syndromes are often complicated by concomitant disorders such as iron deficiency (ID) and diabetes. Comorbidities not only complicate...
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16R-HETE and 16S-HETE Alter Human Cytochrome P450 1B1 through Transcriptional and Allosteric Mechanism
DownloadFall 2022
Cardiac hypertrophy is a complex anomaly of the heart associated with increased muscle mass and thickening of the cell walls in response to accumulative stress. Although this condition occurs naturally, the prolonged state will progress into heart failure or even cause death. Recent studies have...
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Using Intersectionality Theory and Critical Realism for Exploring Heart Failure Telehealth Interventions for Vulnerable Patient Populations: A Scoping Review, Intersectionality-based Analysis, and A Rapid Realist Review
DownloadFall 2022
Background: Heart Failure (HF) is at epidemic levels among older adults, globally. Heart Failure Disease Management Interventions (HFDMIs) enhance self-care and quality of life as well as reduce hospital readmissions, through patient education and follow up, effective treatment, psychosocial...
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Fall 2022
Background The discovery of angiotensin-converting enzyme 2 (ACE2) introduced an alternative protective arm of the renin-angiotensin system (RAS), the ACE2/Angiotensin 1-7 (Ang 1-7)/Mas receptor axis, to counterbalance the more renowned pathogenic angiotensin-converting enzyme (ACE)/Angiotensin...
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Spring 2021
Mechanical circulatory support has become a therapeutic option for children with advanced heart failure. This type of support is often used to bridge patients to heart transplantation with approximately a third of all patients listed for transplant requiring some form of mechanical support. While...
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The Role of Subterminal Hydroxyeicosatetraenoic Acids in the Pathogenesis of Cardiac Hypertrophy
DownloadFall 2021
Cardiac hypertrophy is a complex condition which is characterized by increased mass of the heart muscle. If untreated, cardiac hypertrophy can ultimately lead to heart failure (HF), arrhythmia and sudden death. Accumulating evidence suggest that pathological cardiac hypertrophy is strongly...
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Non-invasive cardiac magnetic resonance imaging techniques for assessment of myocardial fibrosis
DownloadFall 2020
While there may be numerous underlying origins, myocardial fibrosis is a common, unifying finding in various forms of heart disease. Unfortunately, its presence goes beyond simply being a herald of myocardial injury. The alterations in the extracellular space lead to abnormalities in both...
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Physical Activity in Association with Prognostic Determinants Across Heart Failure Continuum
DownloadFall 2020
Heart Failure (HF) is a complex syndrome that greatly contributes to declining physical function in older adults and causes a substantial economic burden for health care systems. Older adults at risk of developing HF typically have other comorbidities. In addition, patients with HF often...
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Fall 2014
Cardiac Fatty acids β-oxidation (FAO) markedly increases during maturation and become the major source of energy for the adult heart. However, excessive rates of FAO can compromise cardiac function in obesity, diabetes, and heart failure. Lysine acetylation has recently been identified as a...
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Spring 2014
Many heart failure (HF) hospital admissions are avoidable with appropriate surveillance and self-care support that HF Clinics can provide. Previous studies conducted vary in approach to surveillance. The goal of this study was to assess the impact of frequency of HF Clinic recall visits on...