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- 2Huang, Biao (Chemical and Materials Engineering)
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CS23D: A web server for rapid protein structure generation using NMR chemical shifts and sequence data
Download2008
Wishart, D.S., Berjanskii, M., Arndt, D., Lin, G., Tang, P., Zhou, J.
CS23D (chemical shift to 3D structure) is a web server for rapidly generating accurate 3D protein structures using only assigned nuclear magnetic resonance (NMR) chemical shifts and sequence data as input. Unlike conventional NMR methods, CS23D requires no NOE and/or J-coupling data to perform...
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Density-dependent variation in lifetime breeding success and natural and sexual selection in Soay rams
Download1999
Smith, J.A., Bancroft, D.R., Clutton-Brock, T.H., MacColl, A.D., Pilkington, J., Coltman, D.W., Pemberton, J.M.
Variation in male lifetime breeding success (LBS) is central to understanding selection, yet it has rarely been measured in natural populations of large mammals. Here, we first describe variation in the opportunity for selection in cohorts of Soay rams (Ovis aries) on the archipelago of St....
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Depauperate genetic variability detected in the American and European bison using genomic techniques
Download2009
Tokarska, M., Demontis, D., Wójcik, J.M., Gregersen, V.R., Loeschcke, V., Pertoldi, C., Coltman, D.
A total of 929 polymorphic SNPs in EB (out of 54, 000 SNPs screened using a BovineSNP50 Illumina Genotyping BeadChip), and 1, 524 and 1, 403 polymorphic SNPs in WB and PB, respectively, were analysed. EB, WB and PB have all undergone recent drastic reductions in population size. Accordingly, they...
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Development of an assay for the identification of campylobacter bacteriophage receptor binding proteins
Development of an assay for the identification of campylobacter bacteriophage receptor binding proteins
Download2012-10-25
Bacterial viruses (phages) are ubiquitous in the environment and are believed to target every bacterial species. Phages utilize receptor binding proteins (RBPs) to bind specifically to their host cell surface. The Campylobacter jejuni phage NCTC 12673 RBP and its capsular polysaccharide (CPS)...
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Disubstituted sialic acid ligands targeting siglecs CD33 and CD22 associated with myeloid leukaemias and B cell lymphomas
Download2014
McBride, Ryan, Fokin, Valery V., He, Yuan, Macauley, Matthew S., Paulson, James C. , Arlian, Britni M., Rillahan, Cory D., Rangarajan, Janani, Schwartz, Erik
The siglec family of sialic acid-binding proteins are endocytic immune cell receptors that are recognized as potential targets for cell directed therapies. CD33 and CD22 are prototypical members and are validated candidates for targeting acute myeloid leukaemia and non-Hodgkin's lymphomas due to...
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Genetic variation in height, branch and needle lengths of Pinus sylvestris L. from Siberia tested in Alberta, Canada
Download2003
Dhir, N.K., Rweyongeza, D., Yeh, F.C., Dancik, B.P.
We performed the analysis of variance and covariance on height, branch length, height to branch length ratio, and needle length measurements from thirty open-pollinated families of Pinus sylvestris L. from Siberia, Russia. This progeny trial was replicated on three sites in central Alberta,...
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Genome sequence and activity of KS10, a transposable phage of the Burkholderia cepacia complex
Download2008
Lynch, Karlene H., Shrivastava, Savita, Seed, Kimberley D., Goudie, Amanda D., Wishart, David S., Stothard, Paul, Dennis, Jonathan J.
Background The Burkholderia cepacia complex (BCC) is a versatile group of Gram negative organisms that can be found throughout the environment in sources such as soil, water, and plants. While BCC bacteria can be involved in beneficial interactions with plants, they are also considered...
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Genome-wide analysis of zygotic linkage disequilibrium and its components in crossbred cattle
Download2012
Jiang, Q., Wang, Z., Yang, R. C., Moore, S. S.
Background Linkage disequilibrium (LD) between genes at linked or independent loci can occur at gametic and zygotic levels known asgametic LD and zygotic LD, respectively. Gametic LD is well known for its roles in fine-scale mapping of quantitative trait loci, genomic selection and evolutionary...
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Genomic sequence and activity of KS10, a transposable phage of the Burkholderia cepacia complex
Download2008
Seed, K.D., Lynch, K.H., Dennis, J.J., Goudie, A.D., Wishart, D.S., Shrivastava, S., Stothard, P.
Background: The Burkholderia cepacia complex (BCC) is a versatile group of Gram negative organisms that can be found throughout the environment in sources such as soil, water, and plants. While BCC bacteria can be involved in beneficial interactions with plants, they are also considered...
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GERp95, a membrane-associated protein that belongs to a family of proteins involved in stem cell differentiation
Download1999
DiMattia, G.E., Hansen, D., Tahbaz, N., Hobman, T.C., Hendricks, L.C., Pilgrim, D., Cikaluk, D.E.
A panel of mAbs was elicited against intracellular membrane fractions from rat pancreas. One of the antibodies reacted with a 95-kDa protein that localizes primarily to the Golgi complex or the endoplasmic reticulum (ER), depending on cell type. The corresponding cDNA was cloned and sequenced and...