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High fructose intake during pregnancy adversely affects insulin resistance, lipid profiles, and affects placental gene expression of nutrient transporters and angiogenesis in rat dams and their pregnant offspring
DownloadSpring 2017
Fructose intake has increased over the past several decades due to high consumption of sugary foods and drinks. In non-pregnant humans and animals, high fructose intake results in hyperlipidemia, insulin resistance and weight gain, although its effects on metabolic adaptations to pregnancy and on...
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Investigation of the Synthesis, Reactivity and Biological Properties of Various 6-Substituted D-Fructose Derivatives
DownloadFall 2017
The detection of small tumors growing in complex organs, including breast tissue, is a challenge in modern medical imaging. The use of positron emission tomography (PET) and tracer molecules containing radionuclei such as 18F have been of significant value to detect small tumors. The commonly...
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Preliminary Analysis of Dietary Sugar Consumption During Pregnancy Using a Potential Biomarker of Urinary Fructose Excretion
DownloadSpring 2014
A 24 hour urinary fructose excretion correlates with total sugar intakes. However, whether or not a random (“spot”) urinary fructose measurement is a reliable biomarker of fructose intake is not known. This study was done to determine the extent to which it is possible to estimate fructose intake...
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Synthesis and Characterization of Novel Radiolabelled Substrates for Imaging of GLUT5 Expression in Human Breast Cancer Using Positron Emission Tomography
DownloadFall 2012
Overactive glucose transport and metabolism has been widely recognized as one of the fundamental hallmarks of cancer and its progression. The facilitative glucose transporter GLUT1 is widely overexpressed in many tumor types compared to their untransformed counterparts. Due to this, the glucose...
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The Effects of Fructose Feeding on the Quantal Catecholamine Release from Adrenal Chromaffin Cells
DownloadFall 2015
Abstract: Adrenal chromaffin cells release catecholamines in response to stress, via the exocytosis of large-dense core granules (LDCGs). Excessive stress responses, however, are harmful and can lead to the development of hypertension. The fructose-fed rats, an animal model with the symptom of...