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Skip to Search Results- 17Graduate and Postdoctoral Studies (GPS), Faculty of
- 17Graduate and Postdoctoral Studies (GPS), Faculty of /Theses and Dissertations
- 12Roy Berg Kinsella Research Ranch
- 12Roy Berg Kinsella Research Ranch/Journal Articles (Kinsella Ranch)
- 5Agricultural, Food and Nutritional Science, Department of
- 5Agricultural, Food and Nutritional Science, Department of/Journal Articles (Agricultural, Food and Nutritional Science)
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Spring 2023
Nutrition of the beef cow during pregnancy influences fetal development and potential changes in phenotype. On average 9-10% of beef cows are below the optimal condition score of 2.5/5 at both pre-breeding and pregnancy tests, indicating potential nutritional stress during gestation (Waldner and...
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DNA methylation patterns derived from fetal vulnerability to maternal smoking relate to future child outcomes
DownloadSpring 2021
Fetuses exposed to maternal smoking during pregnancy (MSP) are at higher risk of developing illnesses such as obesity, diabetes and heart, lung and mental health disease. These disorders are part of a group of non-fatal, non-communicable common complex diseases (CCDs) that form the greatest...
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Assessing the Potential for Hybrid Vigour Within a Species: Disparate Population Breeding of Balsam Poplar
DownloadFall 2021
When two or more species are crossed to produce hybrid progeny, some of them can be expected to yield a growth performance far superior to that of either parent (i.e., hybrid vigour/heterosis). To date, there have been few attempts to examine whether hybrid vigour can be achieved by crossing...
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Anti-Cancer Mechanism of Trastuzumab via Blocking Nuclear HER2 Function and Epigenetic Mechanism of Resistance
DownloadSpring 2020
HER2 receptor tyrosine kinase (encoded by ERBB2 gene) is overexpressed in approximately 25% of all breast cancer tumors (known as HER2-positive breast cancers). Overexpression of HER2 causes overactivation of downstream receptor tyrosine kinase pathways including PI3K/Akt and MAPK pathways and is...
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Oral Porphyromonas gingivalis Infection Induces Epigenetic Changes that Promote Persistence of Cardiovascular Disease Risk
DownloadFall 2020
In the last two decades, periodontitis has become recognized as a risk factor for cardiovascular disease (CVD), a term that encompasses many circulatory disorders, often underpinned by atherosclerosis. One of the major questions regarding this association has been whether elimination of...
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Differential responses in placenta and fetal thymus at 12 days post infection elucidate mechanisms of viral level and fetal compromise following PRRSV2 infection
Download2020-01-01
Van Goor, Angelica, Pasternak, Alex, Walker, Kristen, Hong, Linjun, Malgarin, Carolina, MacPhee, Daniel J., Harding, John C. S., Lunney, Joan K.
Background:A pregnant gilt infected with porcine reproductive and respiratory syndrome virus (PRRSV) can transmit the virus to her fetuses across the maternal-fetal-interface resulting in varying disease outcomes. However,the mechanisms leading to variation in fetal outcome in response to PRRSV...
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Fall 2018
Early mammalian development cannot progress without targeted temporal and spatial expression of genes. Changing the accessibility of DNA to transcriptional machinery is one critical way gene expression is controlled. This process, known as chromatin remodeling, is vital for formation of the...
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Nutritional Factors Impacting Intestinal Lipid Metabolism Using a Model of Low Birth Weight Swine
DownloadSpring 2018
Introduction: Non-communicable diseases (NCDs) such as obesity, type 2 diabetes (T2D) and cardiovascular disease (CVD) are increasing at an alarming rate globally. A common feature in these conditions is increased adiposity leading to insulin resistance (IR). Dyslipidemia is a major contributing...
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Spring 2018
Head and neck squamous cell carcinoma (HNSCC) is the 6th most prevalent cancer worldwide with rates of human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) dramatically increasing. The overexpression of enhancer of zeste homolog 2 (EZH2), a histone methyltransferase...
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Fall 2017
T cell development is a highly dynamic process driven by interactions between developing hematopoietic progenitor cells and numerous cell types that nurture their development. Ultimately, signals detected by developing progenitors lead to the activation of cellular signaling pathways that...