Search
Skip to Search Results- 1Cravetchi, Olga Vladimir
- 1Fontaine, Melanie A
- 1Fouhse, Janelle M
- 1Gelfand, Gary A. J.
- 1Gibril, Mumuni
- 1Golec, Dominic P
-
Anti-Cancer Mechanism of Trastuzumab via Blocking Nuclear HER2 Function and Epigenetic Mechanism of Resistance
DownloadSpring 2020
HER2 receptor tyrosine kinase (encoded by ERBB2 gene) is overexpressed in approximately 25% of all breast cancer tumors (known as HER2-positive breast cancers). Overexpression of HER2 causes overactivation of downstream receptor tyrosine kinase pathways including PI3K/Akt and MAPK pathways and is...
-
Assessing the Potential for Hybrid Vigour Within a Species: Disparate Population Breeding of Balsam Poplar
DownloadFall 2021
When two or more species are crossed to produce hybrid progeny, some of them can be expected to yield a growth performance far superior to that of either parent (i.e., hybrid vigour/heterosis). To date, there have been few attempts to examine whether hybrid vigour can be achieved by crossing...
-
DNA methylation patterns derived from fetal vulnerability to maternal smoking relate to future child outcomes
DownloadSpring 2021
Fetuses exposed to maternal smoking during pregnancy (MSP) are at higher risk of developing illnesses such as obesity, diabetes and heart, lung and mental health disease. These disorders are part of a group of non-fatal, non-communicable common complex diseases (CCDs) that form the greatest...
-
Homology modeling of Suv39h1 and discovery of its small molecule inhibitors by virtual screening and their in vitro validation
DownloadFall 2013
Epigenetic modifications are carried out by specific enzymes and are reversible making them a viable and attractive target to design inhibitors to reset the epigenetic regulatory machinery of the cell and restore it to its normal state. Suppressor of variegation 3-9 homolog 1 (Suv39h1) is a...
-
Litter birth weight phenotype and maternal n-3 long-chain polyunsaturated fatty acid supplementation in pigs
DownloadSpring 2013
Research reported in this thesis investigated effects of n-3 polyunsaturated fatty acid (LCPUFA) supplementation, litter birth weight phenotype, and their possible interactions, on reproductive performance of the gilt and sow and postnatal performance of the litter. In an initial study, LCPUFA...
-
Spring 2023
Nutrition of the beef cow during pregnancy influences fetal development and potential changes in phenotype. On average 9-10% of beef cows are below the optimal condition score of 2.5/5 at both pre-breeding and pregnancy tests, indicating potential nutritional stress during gestation (Waldner and...
-
Nutritional Factors Impacting Intestinal Lipid Metabolism Using a Model of Low Birth Weight Swine
DownloadSpring 2018
Introduction: Non-communicable diseases (NCDs) such as obesity, type 2 diabetes (T2D) and cardiovascular disease (CVD) are increasing at an alarming rate globally. A common feature in these conditions is increased adiposity leading to insulin resistance (IR). Dyslipidemia is a major contributing...
-
Fall 2009
Seneviratne, Ruwani Wickramasooriya
The nutritional value of biodiesel co-products were studied for swine. In Exp. 1, expeller-pressed canola meal was nutritionally characterized and validated for grower-finisher pigs. Expeller-pressed canola meal provided adequate energy and AA; ADG was reduced 3 g/d per 1% expeller-pressed canola...
-
Oral Porphyromonas gingivalis Infection Induces Epigenetic Changes that Promote Persistence of Cardiovascular Disease Risk
DownloadFall 2020
In the last two decades, periodontitis has become recognized as a risk factor for cardiovascular disease (CVD), a term that encompasses many circulatory disorders, often underpinned by atherosclerosis. One of the major questions regarding this association has been whether elimination of...
-
Fall 2017
T cell development is a highly dynamic process driven by interactions between developing hematopoietic progenitor cells and numerous cell types that nurture their development. Ultimately, signals detected by developing progenitors lead to the activation of cellular signaling pathways that...