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2013

Zielnik-Drabik, B., Jurasz, P., Radziwon-Balicka, A., Moncada de la Rosa, C., Ramer, C.

Angiostatin is an angiogenesis inhibitor in part generated by and released from platelets. Since platelets upon thrombus formation can give rise to areas of hypoxia, we investigated the effects of angiostatin on endothelial cell migration and apoptosis during hypoxia. Human microvascular...

Fall 2023

Aburahess, Salah

Angiogenesis, the process of forming new blood vessels from a pre-exciting vasculature, is an essential component of embryonic development, tissue remodelling, wound healing, and tumor growth. This process is strictly regulated by a vast array of cellular signalling pathways involving kinases,...

Fall 2016

Farhan, Maikel AA

Thrombotic microangiopathy (TMA) is a broad term for a range of diseases that usually manifest with rapid failure of the affected organ. Although different in etiology, these diseases share a common pattern of injury originating in the vascular endothelium. In turn, the injured vasculature...

Fall 2024

Alavi, Parnian

Von Willebrand factor (VWF) is a procoagulant protein, which is crucial for blood clot formation and is exclusively expressed in endothelial cells and megakaryocytes. An unregulated increase in VWF levels is associated with elevating the incidence of thrombosis. Elevated VWF levels are observed...

Fall 2016

Tavasoli, Mahtab

Renal glomeruli are specialized capillaries that produce a protein-free ultrafiltrate of plasma at an extremely high rate. Glomerular endothelial cells (EC) and podocytes sustain the integrity of filtration barrier, and glomerular mesangial cells provide intravascular support. Podocytes cover...

Fall 2011

Nakhaei-Nejad, Maryam

Leukocyte extravasation is a fundamental process of the inflammatory responses. The mechanisms that control remodelling of endothelial (EC) shape and adhesive contacts during leukocyte transendothelial migration (TEM) are not completely understood. We studied the role of EC phosphatidylinositol...

Fall 2013

Haddad, George

Thrombotic microangiopathies are group of diseases that refer to clinical and pathological syndromes where endothelial injury results in the manifestations of capillary thrombosis, microangiopathic hemolytic anemia, schistocytosis, and can lead to renal failure. In this thesis we aimed to study...