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Skip to Search Results- 1Choi, Min
- 1Gioia, Laura C.
- 1Hiploylee, Carmen
- 1Klahr, Ana C
- 1McCourt, Rebecca C
- 1Mora Álvarez, María G.
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Fall 2016
Arterial spin labeling (ASL) is a magnetic resonance imaging (MRI) noninvasive method, capable of measuring perfusion, i.e. blood flow, with blood as an intrinsic contrast. ASL measurements of cerebral perfusion are usually acquired at very low spatial resolution (> 60mm3 voxels), for several...
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Fall 2016
Background: Intracerebral Hemorrhage (ICH) is associated with high morbidity and patients commonly suffer motor dysfunction. ICH volume is a significant predictor of outcome, and perihematoma edema may also represent tissue injury. Diffusion Tensor Imaging (DTI) can be used to assess in-vivo...
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Spring 2018
Being able to characterize and assess hemodynamics in patients is regarded as essential in understanding vascular and tissue health for diagnostic purposes. There are many parameters associated with hemodynamics such as intravascular pressure, flow rates and perfusion rates, which are important...
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Fall 2013
Intracerebral hemorrhage (ICH) is a devastating subtype of stroke but the role of increased intracranial pressure (ICP) in ICH is unclear - especially since most studies measure ICP in rodents tethered or under anesthesia or restraint. Thus, ICP was measured using telemetry in untethered, awake...
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Fall 2020
Intracerebral hemorrhage (ICH), when a blood vessel ruptures within the brain, affects approximately 15% of stroke victims in Canada. There are no proven neuroprotective treatments ICH but two therapies, therapeutic hypothermia (TH) and iron-chelators, have gained preclinical and clinical...
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Spring 2017
Introduction: Acute blood pressure (BP) reduction is among the few treatments options available in the acute management of intracerebral hemorrhage (ICH). Recent observational studies have demonstrated the presence of lesions suggestive of ischemia on diffusion-weighted sequences (DWI) on MRI. We...
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Fall 2019
Background: Advancements in stroke imaging have allowed clinicians to more accurately select acute ischemic stroke patients for reperfusion therapies. This has moved patient selection from a time-based to an imaging-based paradigm. With few studies directly assessing the differences between...
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Raised intracranial pressure and tissue compliance after large intracerebral hemorrhages in animal models and patients
DownloadFall 2022
Brain injuries that cause mass effect, including stroke and traumatic brain injury, can increase intracranial pressure (ICP) due to the limited space within the skull. Intracerebral hemorrhage (ICH) is a subtype of stroke in which there is bleeding in the brain. In cases of large bleeds, the...
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Spring 2016
Mild therapeutic hypothermia (HYPO), decreasing brain temperature to 32-35°C, is the gold standard neuroprotectant against ischemia. Cooling also ameliorates several cell death mechanisms in other types of brain injury (e.g., traumatic brain injury). As with many other neuroprotectants, HYPO not...