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Skip to Search Results- 2Al Sayah, Fatima
- 2Elamy, Abdel-Halim H
- 1Achtymichuk, Karly A
- 1Adame Perez, Stephany
- 1Akin, Oguz
- 1Akinwumi, Segun M
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Helicobacter pylori infection in Arctic Indigenous communities: assessing the validity of infection status measures and estimating the effect of bacterial load on gastritis severity
DownloadSpring 2023
Helicobacter pylori (Hp) causes chronic inflammation of the stomach lining, also known as gastritis, in nearly all people with a persistent infection. Chronic inflammation of the stomach lining can lead to atrophy of stomach glands, a condition known as atrophic gastritis, believed to be the...
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Histories, Bodies, Stories, Hungers: The Colonial Origins of Diabetes as a Health Disparity among Indigenous Peoples in Canada
DownloadFall 2018
Indigenous people in Canada suffer disproportionately from health disparities, such as obesity and type 2 diabetes, and I have explored these health disparities among Indigenous peoples through the lens of embodiment. Framed within the Developmental Origins of Health and Disease (DOHaD) model,...
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Spring 2022
Background: In metabolic disease statues, such as diabetes and obesity, dyslipidemia is characterized by a dysregulation of lipid homeostasis, due in part to elevated triglyceride (TG)-rich very low-density lipoprotein (VLDL-TG) production and secretion by the liver. Further, these metabolic...
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In-line Ozonolysis coupled to Mass Spectrometry- A New Dimension of Structural Determination for Lipids
DownloadFall 2014
The location of double bonds within unsaturated lipids can greatly affect their biological functions. Liquid chromatography coupled to mass spectrometry (LC/MS) has become a powerful tool for lipid separation and structural elucidation. However, the determination of double bond position remains...
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Influenza Vaccination in Patients with Diabetes: Exploration of the Healthy User in Pharmacoepidemiology Studies
DownloadFall 2015
Pharmacoepidemiologic studies of preventive medications or therapies are prone to the healthy user bias, as patients who are prescribed and adhere to preventive medications/therapies are likely different than patients not receiving these medications in multiple aspects of their lives. These...
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International Comparison of Time to Treatment Intensification and Rates of Complications in Metformin Monotherapy Treated Type 2 Diabetes Patients
DownloadFall 2018
Type 2 diabetes mellitus is a progressive disease which affects many people in Canada and the United States, and the prevalence of type 2 diabetes is only expected to increase in the future. Pharmacological interventions are a cornerstone of the management of type 2 diabetes as they help to...
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Fall 2020
2-aminoadipic acid (2-AAA) has been identified as an accurate long-term biomarker for the future development of diabetes. An investigation of over 2000 patients found that patients in the upper quartile of initial blood 2-AAA levels showed a 2-4x higher incidence of diabetes development over the...
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J-Coupling Effects on Quantification of the 1.3 ppm Lipid Methylene Resonance with In-Vivo Magnetic Resonance Spectroscopy at 3 T
DownloadFall 2015
Quantification of 1.3 ppm lipid methylene protons by proton magnetic resonance spectroscopy has been shown to be relevant to a number of diseases. Additionally, T2 estimation of 1.3 ppm methylene protons has been used to grade the metastatic potential of colon tumours. J-coupling...
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Fall 2016
Lipidomics is a research field that attempts to achieve the comprehensive analysis of the entire lipidome in a biological system. The emergence and rapid expansion of lipidomic studies is driven by the great advances in chromatographic separation and mass spectrometry. For this dissertation, I...
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Spring 2013
Huntington disease (HD) is a neurodegenerative disorder characterized by motor and cognitive symptoms. In HD patients, the protein huntingtin contains an abnormal expansion of a polyglutamine tract, which leads to the selective dysfunction and death of striatal and cortical neurons. Among other...