Search
Skip to Search Results- 8Cytochrome P450
- 5Epoxyeicosatrienoic acids
- 3Cardiac hypertrophy
- 2Arachidonic Acid
- 2Arachidonic acid
- 2EETs
- 1Alsaleh, Nasser B
- 1Althurwi, Hassan N
- 1Asghar, Muhammad Waheed
- 1BATCHU, SRI NAGARJUN
- 1Chaudhary, Ketul R
- 1El-Sherbeni, Ahmed Abd El-Hakeem
- 3El-Kadi, Ayman (Faculty of Pharmacy and Pharmaceutical Sciences)
- 1Ayman, El-Kadi (Pharmacy and Pharmaceutical Sciences)
- 1Brocks, Dion (Pharmacy and Pharmaceutical Sciences)
- 1Dr. John Seubert (Faculty of Pharmacy and Pharmaceutical Sciences)
- 1El-Kadi, Ayman (Faculty of pharmacy and pharmaceutical sciences)
- 1El-Kadi, Ayman (Pharmacy and Pharmaceutical Sciences)
-
Effects of Inflammation and Non-Steroidal Anti-Inflammatory Drugs on Renin-Angiotensin System and Cytochrome P450 Metabolites of Arachidonic Acid
DownloadSpring 2016
Patients suffering from inflammatory disorders are at higher risk of cardiovascular (CV) morbidity and mortality compared to general population. Nonsteroidal anti-inflammatory drugs (NSAIDs) are used to treat pain and inflammation associated with inflammatory disorders such as rheumatoid...
-
MODULATING CYTOCHROME P450-MEDIATED ARACHIDONIC ACID METABOLISM AS A POTENTIAL NEW TREATMENT MODALITY FOR CARDIAC HYPERTROPHY
DownloadSpring 2017
El-Sherbeni, Ahmed Abd El-Hakeem
Arachidonic acid (AA) metabolism has long been a very appealing target for drug discovery and development efforts. Beside cyclooxygenase and lipoxygenase pathways, AA is also metabolized by the recently recognized cytochrome P450 (P450) pathway, forming several biologically-active...
-
MODULATION OF ARYL HYDROCARBON RECEPTOR (AHR)-REGULATED CARCINOGEN ACTIVATING ENZYMES BY ORGANIC ARSENICALS: A POTENTIAL THERAPEUTIC TARGET
DownloadSpring 2017
Arsenic is a worldwide environmental pollutant that is associated with skin and several types of internal cancers, such as liver, lung, kidney, urinary bladder, and prostate cancers. Recent reports revealed that organic arsenic metabolites, such as trimethylarsine oxide (TMAO), dimethylarsinic...
-
Mechanisms by Which Arachidonic acid Metabolite, Epoxyeicosatrienoic acid Elicit Cardioprotection Against Ischemic Reperfusion Injury
DownloadFall 2011
Epoxyeicosatrienoic acids (EETs) are cytochrome P450 epoxygenase metabolites of arachidonic acid that have cardioprotective properties but the exact mechanism(s) remains unknown. Evidence suggests phosphoinositide 3-kinase (PI3K) and plasma membraneATP-sensitive potassium channels (pmKATP) are...
-
Fall 2012
Ischemic heart disease remains a major cause of illness, disability and death worldwide, as such there remains a need for novel pharmacological agents that protect against myocardial ischemia reperfusion (I/R) injury. Epoxyeicosatrienoic acids (EETs) are cytochrome P450 (CYP) epoxygenase...
-
Spring 2014
Epoxyeicosatrienoic acids (EET) are cytochrome P450 epoxygenase metabolites of arachidonic acid. Evidence shows that they mediate protective effects in the cardiovascular system promoting cell survival. In this thesis, the major focus was to investigate if and how EETs regulate autophagy in...
-
Spring 2016
Mitochondria are at the center of cardiac health and disease. These vital organelles provide most of the energy to the contractile apparatus and play a strategic role in cardiomyocyte survival during cellular stress. Cardiovascular diseases and many aging related diseases are often associated...
-
THE ROLE OF CYTOCHROME P450 AND THEIR ASSOCIATED ARACHIDONIC ACID METABOLITES IN THE INITIATION AND PROGRESSION OF CARDIAC HYPERTROPHY
DownloadSpring 2016
Heart failure (HF) is the leading cause of mortality and disability in adults worldwide. Cardiac hypertrophy is an independent risk factor and one of the major hallmarks of HF. Research in cardiac hypertrophy is considered as a research into the early events in the development of HF. The...
-
The Role of Subterminal Hydroxyeicosatetraenoic Acids in the Pathogenesis of Cardiac Hypertrophy
DownloadFall 2021
Cardiac hypertrophy is a complex condition which is characterized by increased mass of the heart muscle. If untreated, cardiac hypertrophy can ultimately lead to heart failure (HF), arrhythmia and sudden death. Accumulating evidence suggest that pathological cardiac hypertrophy is strongly...
-
The role of cytochrome P450 and the protective effect of EETs against isoproterenol-induced cellular hypertrophy in rat H9c2 cell line
DownloadSpring 2013
Cytochrome P450 (CYP) enzymes have been identified in the heart and their levels have been reported to be altered during cardiac hypertrophy and heart failure. Furthermore, CYP enzymes have been shown to metabolize arachidonic acid to cardioprotective epoxyeicosatrienoic acids (EETs) and...