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Biochemical Characterization of ATP-Binding Cassette Transporter G1 Mediated Cholesterol Efflux
DownloadSpring 2012
ABCG1 mediates cholesterol efflux onto lipidated apolipoprotein A-I and plays an important role in macrophage reverse cholesterol transport, thereby preventing atherosclerosis. However, how ABCG1 mediates cholesterol efflux is unclear. We found that Cys514 located within the third putative...
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Spring 2017
Raman and Raman optical activity (ROA) spectroscopy are a set of especially effective spectroscopic practices for measuring the vibrational transitions of molecules in solution. They are particularly well suited for measurements of aqueous solutions because of the relatively little Raman...
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Spring 2011
The mammalian Na+/H+ exchanger isoform 1 (NHE1) is a ubiquitous membrane protein that exchanges one intracellular H+ for an extracellular Na+, thereby regulating cell pH and volume. NHE1 catalytic activity is mediated by a transmembrane (TM) domain with 12 transmembrane segments. We performed...