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Skip to Search Results- 15Young, T. Kue
- 6Proctor, Spencer D.
- 5Willows, Noreen D.
- 4Field, Catherine J.
- 4Hegele, Robert A.
- 4Prado, Carla M.
- 75Graduate and Postdoctoral Studies (GPS), Faculty of
- 75Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 30Agricultural, Food and Nutritional Science, Department of
- 30Agricultural, Food and Nutritional Science, Department of/Journal Articles (Agricultural, Food and Nutritional Science)
- 17School of Public Health
- 17School of Public Health/Journal Articles (Public Health)
- 75Thesis
- 56Article (Published)
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- 1Conference/Workshop Presentation
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Chemically defined diet alters the protective properties of fructo-oligosaccharides and isomalto-oligosaccharides in HLA-B27 transgenic rats
Download2014
Koleva, Petya, Ketabi, Ali, Dieleman, Levinus A., Gänzle, Michael G., Valcheva, Rosica
Non-digestible oligosaccharides (NDO) were shown to reduce inflammation in experimental colitis, but it remains unclear whether microbiota changes mediate their colitis-modulating effects. This study assessed intestinal microbiota and intestinal inflammation after feeding chemically defined...
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Spring 2011
Niemann-Pick Type C (NPC) disease is an autosomal recessive disorder that results in accumulation of unesterified cholesterol in late endosomes/lysosomes (LE/Ls), leading to progressive neurodegeneration and premature death. Microglia are resident immune cells of the central nervous system, which...
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Chronic Fatigue Mechanisms in Autoimmune Diseases: Lessons from Primary Biliary Cholangitis and Systemic Sclerosis
DownloadFall 2023
Systemic sclerosis (SSc) is an autoimmune disease affecting the body's connective tissues, resulting in progressive fibrosis and vasculopathy. In some cases, individuals with SSc may also develop primary biliary cholangitis (PBC), another autoimmune disease characterized by damage to their...
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Chronic Heart Failure: The Roles of the Tumor Necrosis Factor-Alpha Axis and Left-Atrial Structural and Functional Remodeling
DownloadFall 2014
Heart failure (HF) is a global epidemic, with a substantial burden on healthcare systems. Effective therapies have emerged for patients suffering from HF with reduced ejection fraction (HFREF), but not for those with preserved ejection fraction (HFPEF). Recently, systemic inflammation, driven by...
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2001-06-01
Hegele, Robert A., Huff, Murray W., Young, T. Kue
"We discovered that rare mutations in LMNA, which encodes lamins A and C, underlie autosomal dominant Dunnigan-type familial partial lipodystrophy. Because familial partial lipodystrophy is an extreme example of genetically disturbed adipocyte differentiation, it is possible that common variation...
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Comparative isolation of bacteria from inflamed sites to identify inflammation-tailored bacteria
DownloadSpring 2021
Microbial culture collections are fundamental to microbiology research. However, with the advent of next generation sequencing research, the generation and maintenance of comprehensive culture collections has become deprioritized. As such a need exists for the improved isolation of diverse...
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Comparative variation within the genome of Campylobacter jejuni NCTC 11168 in human and murine hosts
Download2014
Selinger, L. Brent, Taboada, Eduardo N., Uwiera, Richard R. E., Abbott, D. Wade, Inglis, G. Douglas, Thomas, Dallas K., Lone, Abdul G.
Campylobacteriosis incited by C. jejuni is a significant enteric disease of human beings. A person working with two reference strains of C. jejuni National Collection of Type Cultures (NCTC) 11168 developed symptoms of severe enteritis including bloody diarrhea. The worker was determined to be...
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Contributions of Bim and Nur77 to multiple mechanisms of T cell tolerance following high affinity antigen encounter
DownloadSpring 2015
Prevention of autoimmune disease requires the elimination or inactivation of T cells that are highly reactive to self-peptides. During T cell development in the thymus, self-reactive thymocytes undergo negative selection upon receiving a high affinity T cell receptor (TCR) signal following...
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Cree women speak: Intergenerational perspectives on weight gain during pregnancy and weight loss after pregnancy
Download2008
Brennand, Erin A., Vallianatos, Helen, Dannenbaum, David, Petawabano, Beatrice, Raine, Kim, Willows, Noreen D., Stephen, Queenie
Obesity is prevalent among the First Nations population in Canada, with serious associated health risks. Recent studies also indicate that a high percentage of First Nations women are overweight or obese at the start of their pregnancies, with a tendency to retain weight after their children are...
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Fall 2011
The prevalence of childhood obesity has increased dramatically over the last three decades in Canada with substantial consequences for the physical, mental, and economic wellbeing of the population. The overarching objective of this thesis was to examine the various aspects of childhood obesity...