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Skip to Search Results- 3Neupert, W.
- 2Nargang, F. E.
- 1Ahting, U.
- 1Akhnokh, Maria Kodsy
- 1BATCHU, SRI NAGARJUN
- 1Bahitham, Wesam
- 32Graduate and Postdoctoral Studies (GPS), Faculty of
- 32Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 3Biological Sciences, Department of
- 3Biological Sciences, Department of/Journal Articles (Biological Sciences)
- 2Agricultural, Food and Nutritional Science, Department of
- 2Agricultural, Food and Nutritional Science, Department of/Journal Articles (Agricultural, Food and Nutritional Science)
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Spring 2014
The TOB (Topogenesis of Outer membrane β-barrel proteins) complex is composed of the core proteins Tob55 (Sam50), Tob37 (Sam37) and Tob38 (Sam35). The complex facilitates the insertion of all β-barrel and some α-helically anchored integral proteins into the mitochondrial outer membrane (MOM)....
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Biogenesis of Porin of the Outer Mitochondrial Membrane Involves an Import Pathway via Receptors and the General Import Pore of the TOM Complex
Download2001
Nargang, F. E., Pfanner, N., Neupert, W., Blachly-Dyson, E., Forte, M., Krimmer, T., Ryan, M. T., Kassenbrock, K., Rapaport, D., Douglas, M. G., Meisinger, C.
Abstract: Porin, also termed the voltage-dependent anion channel, is the most abundant protein of the mitochondrial outer membrane. The process of import and assembly of the protein is known to be dependent on the surface receptor Tom20, but the requirement for other mitochondrial proteins...
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Characterization of the Mitochondrial Phenotype Associated with Primary Biliary Cholangitis
DownloadSpring 2017
Primary Biliary Cholangitis (PBC) is a chronic liver disease characterized by the immune-mediated destruction of intra-hepatic bile ducts. The autoimmune nature of PBC involves humoral and cell-mediated responses that target endogenous mitochondrial proteins. It is thought that the breakdown of...
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Chronic Fatigue Mechanisms in Autoimmune Diseases: Lessons from Primary Biliary Cholangitis and Systemic Sclerosis
DownloadFall 2023
Systemic sclerosis (SSc) is an autoimmune disease affecting the body's connective tissues, resulting in progressive fibrosis and vasculopathy. In some cases, individuals with SSc may also develop primary biliary cholangitis (PBC), another autoimmune disease characterized by damage to their...
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Fall 2009
The analysis of wide-angle cellular light scattering patterns is a challenging problem. Small changes to the organization, orientation, shape, and optical properties of scatterers and scattering populations can significantly alter their complex two-dimensional scattering signatures. Because of...
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Fall 2017
The pathological events initiating diabetic cardiac changes in response to chronic hyperglycemia and hyperinsulinemia remain unclear. Due to the high metabolic activity of the heart, and its sensitivity to acute changes in oxygen and substrate flux, mitochondrial dysfunction has been proposed as...
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Fall 2020
Eukaryotic cells are characterized by the presence of membrane-bound organelles. Close proximity between organelles has been observed for decades, but only recently we have really started to understand the importance of these contacts for cellular function. These contacts consist of areas of...
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Fall 2016
Multiple sources suggest that insulin resistance and derangements of cardiac metabolism are among the earliest signs of type-2 diabetes detected in the heart. Unfortunately, limited evidence reflects early changes in cardiac mitochondrial metabolism linked to the development of this disease....
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Fall 2013
Deregulated TNF signaling with elevated or decreased levels of TNF-induced apoptosis causes numerous inflammatory and cancerous diseases. Thus, there is a clear need to identify cellular proteins that regulate cell fate in the presence of TNF. RNA interference technology provides an excellent...
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2012
Wan, Zhongxiao, MacDonald, Tara, Wright, David C., Holloway, Graham P., Chan, Catherine B., Perry, Christopher G.
Background Adipose tissue mitochondria have been implicated as key mediators of systemic metabolism. We have shown that IL-6 activates AMPK, a mediator of mitochondrial biogenesis, in adipose tissue; however, IL-6−/− mice fed a high fat diet have been reported to develop insulin resistance. These...