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- 5Comparative immunology
- 4Immunoregulatory receptors
- 4Neutrophil
- 4SEM
- 3Innate immunity
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Zebrafish (Danio rerio) Leukocyte Immune-Type Receptor (DrLITR) Variable Control of the Phagocytic Response
DownloadSpring 2023
To combat microbial invaders, immune cells elicit a range of potent antimicrobial effector responses coordinated by complex intracellular signalling events. These events are initiated by the engagement of cell surface-expressed proteins, termed immunoregulatory receptors, that bind to and...
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Identification and Molecular Characterization of Zebrafish (Danio rerio) Leukocyte Immune-Type Receptors (DrLITRs)
DownloadSpring 2020
In response to foreign invaders, innate immune cells use cell surface-expressed receptors to trigger intracellular signalling cascades that control various effector responses designed to destroy microbes. These specialized receptors are known as immunoregulatory receptors and structurally they...
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Examination of channel catfish (Ictalurus punctatus) leukocyte immune-type receptor-mediated crosstalk regulation of phagocytosis
DownloadFall 2020
Across vertebrates, innate immune cells are capable of initiating a range of potent effector responses that are designed to destroy or contain foreign microbial invaders. The execution and regulation of various innate cellular responses is mediated by a dedicated repertoire of cell...
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Development of imaging-based techniques to examine signalling properties of channel catfish (Ictalurus punctatus) leukocyte immune-type receptors (IpLITRs)
DownloadSpring 2017
Cells of the innate immune system have the ability to rapidly detect and eliminate pathogens using surface-expressed immunoregulatory receptors that translate extracellular binding into effector functions such as degranulation, cytokine secretion, cell-mediated cytotoxicity, and phagocytosis....
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Fall 2017
Protein prenylation is the post-translational addition of isoprenoid lipid moieties to proteins, which regulates their subcellular localization and function. Farnesyl or geranylgeranyl isoprenoids are covalently linked to cysteines residues in a C-terminal prenylation recognition sequence in...
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Spring 2015
Interferon Inducible Transmembrane Proteins (IFITMs) can restrict the entry of a wide range of viruses. IFITM3 localizes to endosomes and can potently restrict the replication the influenza A virus (IAV), and several other viruses that also enter host cells through the endocytic pathway. Given...
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Fall 2013
In response to pathogens, immune cells induce protective effector functions, such as degranulation, phagocytosis and cytokine secretion, which are initiated by stimulatory or inhibitory immunoregulatory receptors expressed on leukocytes. Using a fish immunological model system, the focus of my...