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Skip to Search Results- 1Ahmed, Kazi Tanveer
- 1Al Cook
- 1Ali, Declam
- 1Aroonassala Patten, Shunmoogum
- 1Attia, Karen
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- 34Graduate and Postdoctoral Studies (GPS), Faculty of
- 34Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 1Rehabilitation Medicine, Faculty of
- 1Rehabilitation Medicine, Faculty of/General Rehabilitation Medicine
- 1Biological Sciences, Department of
- 1Biological Sciences, Department of/Journal Articles (Biological Sciences)
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Transcriptional regulation of the zebrafish activation-induced cytidine deaminase (AID) gene
DownloadFall 2012
Activation-induced cytidine deaminase (AID, encoded by Aicda) mediates affinity maturation of immunoglobulin genes. Early studies in mammals indicated that the transcription of Aicda was regulated by a number of transcriptional regulatory regions, including a B-cell specific enhancer in the...
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Transcriptomic analysis of zebrafish prion protein mutants supports conserved cross-species function of the cellular prion protein; and zebrafish as a model for cisplatin induced ototoxicity and transition metals as potential ligands for Tlr4ba and Tlr4bb
DownloadFall 2021
The work presented in this thesis is split between two projects. The first utilises prp1 and prp2 knockout zebrafish to investigate physiological functions of the cellular prion protein (PrPC). The second builds upon the use of zebrafish as a model for hearing loss to confirm a role of toll-like...
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Using Local and Traditional Knowledge to Define a Digital Library for the Inuvialuit Settlement Region
Download2016-09-01
Stobbs, R. , Campbell, Sandy, Farnel, S. , Piltingsrud, A. , Shiri, A. , Rathi, D. , Maloney, E. , Cockney, C.
The Digital Library North (DLN) project is a research and development collaboration between the Inuvialuit Cultural Resource Centre (ICRC) located in Inuvik, in Canada’s Northwest Territories and the University of Alberta School of Library and Information Studies in Edmonton, Alberta. The...
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Using a Zebrafish Animal Model to Identify the First Candidate Gene for Pigmentary Glaucoma
DownloadSpring 2019
Premelanosome protein (PMEL) was identified as a candidate gene for the development of pigment dispersion syndrome (PDS) and pigmentary glaucoma (PG) in humans. Mutations in PMEL were shown to cause pigment and ocular defects in several animals but there is currently no known PMEL associated...
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Spring 2012
The escape response in zebrafish is mediated in part by the Mauthner cell and its two homologues, MiD2cm and MiD3cm. In adult fish, the Mauthner cell fires a single action potential when activated while the homologues fire multiple action potentials. Their distinct firing properties are partially...
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Zebrafish embryos exposed to alcohol undergo abnormal development of motor neurons and muscle fibers
DownloadFall 2009
Children with Fetal Alcohol Spectrum Disorder have significantly delayed motor skills, and deficiencies in reflex development. The reasons underlying these motor deficits are not fully understood. The purpose of this thesis was to investigate the effect of embryonic exposure to ethanol (EtOH) on...
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Zic transcription factors regulate retinoic acid metabolism during zebrafish neural development
DownloadSpring 2012
Retinoic acid (RA) has a crucial role in embryonic nervous system development - controlling anterior-posterior patterning, neural differentiation, and cell proliferation. During zebrafish embryogenesis, levels of RA are tightly regulated by the combinatorial action of synthesis and degradation...