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- 3Bell, Rhonda C.
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Characterization of Human Pancreatic Beta-cell Progenitors as a Means to Alleviate the Shortage of Donor Tissue for Islet Transplantation
DownloadFall 2012
The current shortage of islet tissue from cadaveric human donors is not sustainable and will preclude islet transplantation from becoming a widespread therapeutic treatment for those with type 1 diabetes. A potential alternative source of tissue may be through isolating, expanding, and...
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Characterizing the effects of differentially adapted influenza PB2 proteins on duck MAVS-mediated interferon beta signaling
DownloadFall 2015
The influenza A viral RNA polymerase is responsible for viral replication and greatly affects influenza A virus (IAV) virulence and host range. The PB2 influenza polymerase subunit is the primary polymerase determinant of influenza host range and virulence. It was previously shown that PB2...
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2013-03-14
Sherman, Philip - Scientific Director, CIHR Institute of Nutrition, Metabolism and Diabetes (INMD)
Dr. Philip Sherman (Scientific Director, CIHR Institute of Nutrition, Metabolism and Diabetes [INMD]) outlined the 2009-2014 Strategic Priorities of INMD. These include Food and Health; Environments, Genes, & Chronic Disease; Obesity and Healthy Body Weight: Seeking Solutions; and Continuum of...
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Clinical and Translational Studies Advancing Clinical Implementation of Stem Cell-Derived Islet Transplantation
DownloadSpring 2024
Twenty-years ago Shapiro et al. revolutionized islet transplantation (ITx), realizing the potential for a cell-based diabetes treatment. Despite improvements, ITx remains restricted by organ donor limitations and immunosuppression. Stem cell (SC)-derived ITx (SC Tx) could eliminate these...
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Collective knowledge: Using a Consensus Conference approach to develop recommendations for physical activity and nutrition programs for persons with Type 2 diabetes
Download2012-01-01
Berry, T. R., Chan, C., Walker, J., Bell, R.
The purpose of this consensus conference was to have a lay panel of persons with type 2 diabetes (T2D) work in collaboration with an expert panel of diabetes professionals to develop strategies designed to improve dietary and physical activity adherence in persons with T2D. Lay panel participants...
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Collective knowledge: Using a consensus conference approach to develop recommendations for physical activity and nutrition programs for persons with type 2 diabetes
Download2012
Bell, Rhonda C., Walker, Jessica, Chan, Catherine B., Berry, Tanya R.
The purpose of this consensus conference was to have a lay panel of persons with type 2 diabetes (T2D) work in collaboration with an expert panel of diabetes professionals to develop strategies designed to improve dietary and physical activity adherence in persons with T2D. Lay panel participants...
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Contributions of Bim and Nur77 to multiple mechanisms of T cell tolerance following high affinity antigen encounter
DownloadSpring 2015
Prevention of autoimmune disease requires the elimination or inactivation of T cells that are highly reactive to self-peptides. During T cell development in the thymus, self-reactive thymocytes undergo negative selection upon receiving a high affinity T cell receptor (TCR) signal following...
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Contributions to chronic disease prevention and control: studies among the Kivalliq Inuit since 1990
Download2003-12-01
"A population-based health interview and examination survey of 8 Inuit communities in the Kivalliq region of Nunavut, Canada, during the early 1990s has resulted in an increased understanding of the burden and extent of cardiovascular diseases and diabetes and their risk factors such as genetics,...
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Fall 2012
Establishing mixed hematopoietic chimerism is a promising approach to develop donor-specific tolerance to transplanted organs. Establishing tolerance may eliminate the need for long-term immunosuppressive therapy, prevent chronic rejection and in the case of Type 1 Diabetes (T1DM), reverse...
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2019-12-10
Pepper, Andrew, Korbutt, Gregory
NFRF Exploration awarded in 2020: While the global incidence of type 1 diabetes (T1D) continues to rise, it is now clear that transplantation of human pancreatic islets of Langerhans, into the patients’ liver, can successfully restore glycemic control. Despite marked progress in clinical islet...