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Histories, Bodies, Stories, Hungers: The Colonial Origins of Diabetes as a Health Disparity among Indigenous Peoples in Canada
DownloadFall 2018
Indigenous people in Canada suffer disproportionately from health disparities, such as obesity and type 2 diabetes, and I have explored these health disparities among Indigenous peoples through the lens of embodiment. Framed within the Developmental Origins of Health and Disease (DOHaD) model,...
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2012
Barnard, D., Norton, P. G., Batra-Garga, N., Cummings, G. G., Estabrooks C. A., Cranley, L. A.
Background: In Canada, healthcare aides (also referred to as nurse aides, personal support workers, nursing assistants) are unregulated personnel who provide 70-80% of direct care to residents living in nursing homes. Although they are an integral part of the care team their contributions to the...
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Impaired de novo choline synthesis explains why phosphatidylethanolamine N-methyltransferase-deficient mice are protected from diet-induced obesity
Download2010
Kuo, Ming-Shang, Dyck, Jason R. B., Sletten, Torunn, Proctor, Spencer D., Jacobs, René L., Lingrell, Susanne, Cao, Guoqing, Peake, David A., Kennedy, Brian P., Zhao, Yang, Vance, Dennis E., Koonen, Debby P. Y., Su, Brian
Phosphatidylcholine (PC) is synthesized from choline via the CDP-choline pathway. Liver cells can also synthesize PC via the sequential methylation of phosphatidylethanolamine, catalyzed by phosphatidylethanolamine N-methyltransferase (PEMT). The current study investigates whether or not hepatic...
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Influenza Vaccination in Patients with Diabetes: Exploration of the Healthy User in Pharmacoepidemiology Studies
DownloadFall 2015
Pharmacoepidemiologic studies of preventive medications or therapies are prone to the healthy user bias, as patients who are prescribed and adhere to preventive medications/therapies are likely different than patients not receiving these medications in multiple aspects of their lives. These...
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Spring 2013
Immunogenicity of intramuscular influenza vaccine is suboptimal in organ transplant recipients although intradermal vaccine may be superior by targeting dermal dendritic cells to stimulate a response. 229 patients were randomized to IM or high-dose ID vaccine during the 2010-11 season. Pre- and...
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International Comparison of Time to Treatment Intensification and Rates of Complications in Metformin Monotherapy Treated Type 2 Diabetes Patients
DownloadFall 2018
Type 2 diabetes mellitus is a progressive disease which affects many people in Canada and the United States, and the prevalence of type 2 diabetes is only expected to increase in the future. Pharmacological interventions are a cornerstone of the management of type 2 diabetes as they help to...
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Fall 2020
2-aminoadipic acid (2-AAA) has been identified as an accurate long-term biomarker for the future development of diabetes. An investigation of over 2000 patients found that patients in the upper quartile of initial blood 2-AAA levels showed a 2-4x higher incidence of diabetes development over the...
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Spring 2010
These two studies investigate the immune responses of lung and kidney transplant recipients to the influenza vaccine. The study involving kidney transplant recipients developed a novel flow cytometry assay to measure cell-mediated immunity in response to influenza vaccination. The activation of...
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2011
Walker, J., Bell, R., Chan, C., Berry, T. R.
This article presents the methodology and recommendations from a consensus conference hosted in May 2011 by the Physical Activity and Nutrition for Diabetes in Alberta (PANDA) research project. The goal of the conference was to create physical activity and nutrition recommendations for people...
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Long-term Impacts of Early Life Antibiotic Exposure on Intestinal Microbiota and Metabolic Disease
DownloadFall 2015
Although genetic factors, diet choices and sedentary lifestyle have long been considered main risk contributors for obesity and diabetes mellitus, years of study show that these factors cannot fully explain the increasing rate of worldwide metabolic disease. Epidemiological studies in recent...