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Skip to Search Results- 1Baleja, James D.
- 1Elliott, John Francis.
- 1Gibeault, Rebecca L
- 1Hu, MiYao
- 1Kulepa, Ayodeji N
- 1Lacasse, Jonathan J
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Fall 2010
Herpes Simplex Virus Type 1 (HSV-1) establishes latent infections in neurons in vivo and lytic infections in epithelial cells and fibroblasts. During latent infections, HSV-1 transcription is restricted and the genomes are not replicated. Latent HSV-1 genomes are chromatinized, such that...
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Spring 2022
Primary herpes simplex virus 1 (HSV-1) infections are common in childhood, affecting mainly the oropharyngeal mucosa. The virus is then transported to the neuronal bodies in the trigeminal ganglia, where it establishes lifelong latency. Although latent infections are asymptomatic, HSV-1...
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Fall 2010
Asf1 is a conserved H3/H4 histone chaperone with multiple functions in chromatin modulation. Using budding yeast as a model, we identify new pathways of Asf1 function, and expand current knowledge regarding the known roles of Asf1. First, we uncover novel genetic interactions between ASF1 and...
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Fall 2012
Chromatin structure is important aspect of transcriptional regulation. Replication-coupled (RC) nucleosome assembly is the process of depositing newly synthesized H3-H4 onto nascent DNA behind the replication fork, mediated by the histone chaperones Asf1, CAF-1, and Rtt106. The experiments...
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Spring 2022
The DNA damage response (DDR) is critical for maintaining genomic integrity and prevention of genotoxic consequences leading to carcinogenesis. The DDR signaling cascade results either in the activation of the repair pathway, or initiation of apoptosis if the repair is not possible. Many...
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Fall 2017
Herpes simplex virus 1 (HSV-1) is a nuclear-replicating, double-stranded (ds) DNA virus. HSV-1 genes are expressed in a coordinate manner. The tegument protein VP16 first activates expression of the five immediate-early (IE) genes. Two IE proteins, ICP4 and ICP0, then activate early (E) and...