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Skip to Search Results- 1Alabi, Adekunle
- 1Alrabeeah, Abdollah A. M.
- 1Bourrie, Benjamin
- 1Causton, Norman D.
- 1Chung, Jiyun
- 1Deng, Shijun
- 4Department of Surgery
- 2Centre for Neuroscience
- 2Department of Agricultural, Food, and Nutritional Science
- 2Department of Biological Sciences
- 2Department of Medicine
- 2Department of Physiology
- 2Kar, Satyabrata (Medicine and Psychiatry)
- 1Anderson, Colin (Department of Surgery) (Department of Medicine and Medical Microbiology & Immunology)
- 1Ding, Jie (Department of Surgery)
- 1Dr. Posse de Chaves, Elena (Pharmacology)
- 1Fedorak, Richard (Medicine)
- 1Heather McDermid (Biological Sciences)
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Spring 2014
Alzheimer’s disease (AD) is the most common form of dementia in the elderly. The major pathological features of AD are extracellular amyloid plaques, intracellular neurofibrillary tangles and neuronal loss. Amyloid beta (Aβ) peptide, the main component of the amyloid plaques, has been proposed to...
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Biochemical Characterization of ATP-Binding Cassette Transporter G1 Mediated Cholesterol Efflux
DownloadSpring 2012
ABCG1 mediates cholesterol efflux onto lipidated apolipoprotein A-I and plays an important role in macrophage reverse cholesterol transport, thereby preventing atherosclerosis. However, how ABCG1 mediates cholesterol efflux is unclear. We found that Cys514 located within the third putative...
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Characterization of hypertrophic scar formation in nude and knockout mice deficient in T, B and natural killer cells
DownloadSpring 2012
Introduction: Hypertrophic scar (HSc) is a fibroproliferative disorder lacking a relevant animal model. Our objective is to characterize proliferative scars in human xenografts generated after grafting human skin onto mice deficient in T, B and natural killer cells. Methods: Nude, T-cell receptor...
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Spring 2010
CECR1 (cat eye syndrome chromosome region, candidate 1) is located on chromosome 22q11.2. Duplication of this region results in the human disorder cat eye syndrome (CES), which includes a variety of heart defects. CECR1 is suggested to be dosage sensitive, based on a predicted role in controlling...
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Spring 2013
Alzheimer’s disease (AD) is a complex neurodegenerative disorder believed to be triggered by the accumulation of β-amyloid (Aβ)-related peptides derived from the proteolytic processing of amyloid precursor protein (APP). Research over the last two decades has shown that alterations in the levels...
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Spring 2011
Niemann-Pick Type C (NPC) disease is an autosomal recessive disorder that results in accumulation of unesterified cholesterol in late endosomes/lysosomes (LE/Ls), leading to progressive neurodegeneration and premature death. Microglia are resident immune cells of the central nervous system, which...
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Culture and Characterization of Kefir Organisms to Reproduce the Health Benefits of Traditional Kefir
DownloadSpring 2020
Fermented dairy products such as kefir have long been associated with a host of health benefits; however, the role that microbial composition has in these benefits has not been properly examined. This research aimed to examine how kefir impacts host metabolic health, as well as how alterations to...
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Spring 2012
Human cytomegalovirus (HCMV) is implicated in several vascular diseases through endothelial dysfunction. Most of the research on CMV has focused on either congenital CMV infections or CMV disease in immunocompromised hosts; however, CMV has also been associated with vascular diseases in...