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Skip to Search Results- 4Gänzle, Michael G.
- 3Valcheva, Rosica
- 2Dieleman, Levinus
- 2Dieleman, Levinus A.
- 2Farhangfar, Arazm
- 2Ketabi, Ali
- 18Graduate and Postdoctoral Studies (GPS), Faculty of
- 18Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 6Agricultural, Food and Nutritional Science, Department of
- 6Agricultural, Food and Nutritional Science, Department of/Journal Articles (Agricultural, Food and Nutritional Science)
- 1Biochemistry, Department of
- 1Biochemistry, Department of/Journal Articles (Biochemistry)
- 3Department of Biochemistry
- 3Faculty of Nursing
- 2Department of Agricultural, Food, and Nutritional Science
- 2Department of Medicine
- 2Faculty of Pharmacy and Pharmaceutical Sciences
- 1Department of Agricultural, Food and Nutritional Science
- 1Baksh, Shairaz (Medical Sciences- Pediatrics)
- 1Baracos, Vickie (Oncology, Agricultural, Food, and Nutritional Science)
- 1Brindley, David N. (University of Alberta, Biochemistry)
- 1Dieleman, Levinus (Medicine)
- 1Dr Vera Mazurak, Agricultural, Food and Nutritional Science
- 1Dr. Afsaneh Lavasanifar (Faculty of Pharmacy and Pharmaceutical Sciences)
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A Novel Comparative Analysis Approach to Personalize Chemotherapy Dose Calculation in Early Breast Cancer
DownloadFall 2018
Background Worldwide, body surface area [BSA] is used to calculate chemotherapy dose. The BSA formula was originally developed in 1916, derived from height and weight, with no consideration of other patient characteristics. Most chemotherapy agents have a narrow therapeutic index and are...
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Fall 2011
This study determined how chemotherapy treatment for colorectal cancer alters hepatic fat metabolism. Livers were isolated from tumor-bearing animals after one and two cycles of chemotherapy consisting of irinotecan plus 5-fluorouracil. Fatty acid amounts and composition within triglycerides (TG)...
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Chemically defined diet alters the protective properties of fructo-oligosaccharides and isomalto-oligosaccharides in HLA-B27 transgenic rats
Download2014
Koleva, Petya, Ketabi, Ali, Dieleman, Levinus A., Gänzle, Michael G., Valcheva, Rosica
Non-digestible oligosaccharides (NDO) were shown to reduce inflammation in experimental colitis, but it remains unclear whether microbiota changes mediate their colitis-modulating effects. This study assessed intestinal microbiota and intestinal inflammation after feeding chemically defined...
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Fall 2010
Escalating cancer rates and an increase in the complexity and duration of chemotherapy regimens have brought the issue of cancer treatment at home to the forefront. For the participants of this study, home chemotherapy was offered as a potential treatment choice. Ten patients who accepted were...
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Cognitive Dysfunction in non-Hodgkin's Lymphoma Patients Treated with Front-Line Chemotherapy
DownloadSpring 2015
Despite the research to date, the characteristics and impact of cognitive dysfunction (CD) in cancer patients following chemotherapy is still not well understood. It is estimated approximately 20% of patients will manifest measurable cognitive deficits on neuropsychological testing...
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Fall 2015
Microtubules are cellular structures that are crucial to many cellular functions including maintenance of cell shape, vesicular transport, and cell division. The dynamic instability of microtubules is the basic feature which enables them to do their cellular functions. Their pivotal role in cell...
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Development of polymer and lipid based nano-delivery systems for targeted cancer chemotherapy
DownloadFall 2012
Conventional chemotherapy agents can kill tumor cells and inhibit tumor growth, but they produce severe side effects on normal cells at the same time. To shift the balance towards tumoral effects, it would be desirable to direct the anti-cancer drug towards tumor while restricting drug access to...
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Eicosapentaenoic and Docosahexaenoic Fatty Acids Modify Skeletal Muscle Fat Infiltration in an Animal Model of Colorectal Cancer Receiving Chemotherapy
DownloadSpring 2017
Background: Myosteatosis is defined as low skeletal muscle radio-density with elevated amounts of intermuscular adipose tissue, assessed using computed tomography. Myosteatosis has been recently observed to be associated with mortality in people with cancer. Previous work from our lab reported...
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Inulin and fructo-oligosaccharides have divergent effects on colitis and commensal microbiota in HLA-B27 transgenic rats
Download2012-01-01
Koleva, Petya, Dieleman, Levinus, Sun, Xu, Gänzle, Michael G., Valcheva, Rosica
Modulation of intestinal microbiota by non-digestible carbohydrates may reduce inflammation in inflammatory bowel disease (IBD). The aim of the present study was to assess the effects of inulin and fructo-oligosaccharides (FOS) on intestinal microbiota and colitis in HLA-B27 transgenic rats, a...
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2012
Ketabi, Ali, Baracos, Vickie E., Field, Catherine J., Lin, Xiaoxi, Xue, Hongyu, Bibova, Ilona, Gänzle, Michael G., Dieleman, Levinus A., Sawyer, Michael B.
Intestinal microbiota mediate toxicity of irinotecan (CPT-11) cancer therapies and cause systemic infection after CPT-11-induced loss of barrier function. The intestinal microbiota and their functions are thus potential targets for treatment to mitigate CPT-11 toxicity. However, microbiota...