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Skip to Search Results- 1Abdelmoneim, AS
- 1Agellon, Luis B.
- 1Berry, K.M.
- 1Callander, D.
- 1Chow, Ava Kalyca
- 1Domnich, Vladislav
- 10Graduate and Postdoctoral Studies (GPS), Faculty of
- 10Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 1Biological Sciences, Department of
- 1Biological Sciences, Department of/Journal Articles (Biological Sciences)
- 1Biochemistry, Department of
- 1Biochemistry, Department of/Journal Articles (Biochemistry)
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Fall 2015
2015 marks the 50th anniversary of Moore's law, which has described the exponential progress in semiconductor patterning technologies, enabling creation of smaller circuitry features at greater densities. These continued hardware developments, economically mass manufactured, have made possible...
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Building Evidence to Assess a Drug Safety Signal: the Association between Sulfonylureas and Adverse Cardiovascular Events
DownloadFall 2015
All drugs have the potential to cause adverse events that can result in hospitalization or death. In order to protect the public health, it is critical to employ methods to detect and assess adverse drug events in a timely manner. One of the most controversial and long standing drug safety issue...
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Control of D-Spacing and Graphitic Defects in Asphaltene-Derived Hard Carbons for Energy Storage
DownloadSpring 2024
With the increasing demand for energy storage and declining lithium stores around the globe, sodium is emerging as an alternative source due to its natural abundance and similar reaction kinetics and chemical properties to lithium. While sodium-ion and lithium-ion batteries started development at...
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COUP-TF1 antagonizes Nkx25-mediated activation of the calreticulin gene during cardiac development
Download2001-01-01
Guo, Lei, Lynch, Jeffrey, Nakamur, Kimitoshi, Fliegel, Larry, Kasahara, Hideko, Izumo, Seigo, Komuro, Issei, Agellon, Luis B., Michalak, Marek
Calreticulin, a Ca2+ binding chaperone of the endoplasmic reticulum, is also highly expressed in the embryonic heart, and knockout of the calreticulin gene is lethal during embryogenesis because of impaired cardiac development. The protein is down-regulated after birth, and elevated expression of...
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2017-04-01
Hogan, James D., Farbaniec, Lukasz, Mallick, Debjoy, Domnich, Vladislav, Kuwelkar, Kanak, Sano, Tomoko, McCauley, James W., Ramesh, Kaliat T.
In this paper, the impact-induced fragmentation of a commercially available hot-pressed boron carbide is explored. Fragmentation has been noted previously by many authors to be important in the impact performance of advanced ceramics, and so this paper seeks to provide some of the first...
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Intracellular regulation of matrix metalloproteinase-2 activity: the roles of caveolin-1 and troponin I phosphorylation
DownloadFall 2010
Matrix metalloproteinase‐2 (MMP‐2) was recently revealed to have targets and actions within the cardiac myocyte. In ischemia/reperfusion (I/R) injury, MMP‐2 is activated and degrades troponin I (TnI) and α‐actinin. The regulation of intracellular MMP‐2 activity is relatively unknown and is thus...
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Spring 2011
Angiotensin II signals cardiovascular disease through metalloproteinases including MMP-2, MMP-7 and ADAM-17/TACE. We hypothesized that these metalloproteinases regulate each other at the transcriptional level. Further, MMP-2, being a major gelatinase in cardiac and vascular tissue, could mediate...
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2007
Berry, K.M., Erickson, T., Callander, D., Koss, R., Ngai, J., Stout, J., Waskiewicz, A.J., Wuennenberg-Stapleton, K., Moens, C.B., Hagey, D.W., French, C.R.
Background Pbx genes encode TALE class homeodomain transcription factors that pattern the developing neural tube, pancreas, and blood. Within the hindbrain, Pbx cooperates with Hox proteins to regulate rhombomere segment identity. Pbx cooperates with Eng to regulate midbrain-hindbrain boundary...
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Plasma Transferred Arc Additive Manufacturing Using 17-4 Precipitation Hardened Stainless Steel
DownloadSpring 2021
Plasma transferred arc additive manufacturing (PTA-AM) is a newly developed additive manufacturing (AM) process for the manufacturing of large industrial parts for the resource sector. A common material used in numerous industries is 17-4 precipitation hardened (PH) stainless steel, mainly due...