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Dependence of the Interfacial Adhesion between Two Different Types of Material on their Electron Work Function and Electrical Conductivity
DownloadFall 2021
We observed and investigated a novel interfacial phenomenon related to the dependence of interfacial bonding or adhesive force (Fad) between two substances on the difference in their Electron Work Functions (EWF) or Δφ, and developed a model to quantify such a dependence. First, using...
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Design and evaluation of a new Lewis acid-assisted Lewis acid catalyst system and further applications of a double-allylation reagent
DownloadFall 2009
Asymmetric synthesis is one of the most important areas of organic chemistry. Despite of the prevalence of asymmetric catalysts, there is still room for improved catalyst systems. Chapter 2 describes the design and evaluation of a new Lewis acid-assisted Lewis acid (LLA) catalyst system. Many...
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Design, Development and Mechanistic Study of Ruthenium-Based Catalysts for the Hydrogenation of Imides and Amides
DownloadSpring 2014
Prior mechanistic studies demonstrate that trans-[RuH2((R)-BINAP)((R,R)-dpen)] is a remarkably active carbonyl reducing agent at low-temperatures in THF-d8. This dissertation describes the monohydrogenation of cyclic meso-imides using this catalyst and related complexes under mild conditions....
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Development and Application of Protected Amino Acids for the Installation of Stable Post-translational Modifications Using Solid-Phase Peptide Synthesis
DownloadFall 2022
This thesis describes the synthesis of non-canonical amino acid building blocks and their use in solid-phase peptide synthesis (SPPS) to explore peptidic drug analogues based on natural products. We replaced sensitive functionalities found in the structure of naturally produced peptides with...
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Development of Ir- and Rh-Catalyzed Deoxygenation and Carbene Cross Coupling Reactions of Allylic Carbonates
DownloadFall 2016
Transition metal-catalyzed allylic substitution reactions are widely used for the selective formation of new bonds. This class of reaction has been extensively studied with a variety of nucleophiles and under optimized conditions that will furnish product in high yield and with high chemo-,...
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Fall 2019
Carboxylic acids are a ubiquitous class of molecules in the field of organic chemistry and represent versatile building blocks in synthetic chemistry. Methods that enable the formation of new carbon–carbon or carbon–heteroatom bonds from carboxylic acids via the extrusion of carbon dioxide can...
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Spring 2012
The study of heterobimetallic complexes (having two different metal atoms) involves combining the unique properties of each metal, which can give rise to interesting contrasts in reactivity compared to either metal alone. With two different metals incorporated into one complex, a more diverse...
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Earth-Abundant Transition Metal Hydride Complexes for Dehydrocoupling and Hydrosilylation Catalysis
DownloadFall 2015
The research presented in this thesis details the synthesis of transition metal hydride complexes, with the focus on utilising these complexes for (a) the dehydrocoupling of amine-borane adducts, and (b) the hydrosilylation and hydroboration of unsaturated organic moieties. In both instances,...
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Effects of Size and Coalescence on the Interfacial Dynamics of Nanoparticles: A Molecular Dynamics Study
DownloadFall 2015
Normally chemically inert materials such as Au have been found to be catalytically active in the form of particles whose size is about 1 nm. Direct and indirect observations of various types of metal nanoparticles (NPs) in this size range, under catalytically relevant conditions for fuel-cell...
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Empowering the Base Metals: Rational Design of Homogeneous Catalysts for Hydrotreatment, and Reduction of Organic Unsaturates
DownloadFall 2013
Hydrocarbon-soluble, low-coordinate, phosphoranimide-supported complexes of the base metals (iron, cobalt and nickel) were developed and evaluated for a range of stoichiometric and catalytic bond-forming and bond-breaking transformations. An unprecedented family of tetrametallic clusters of Co(I)...