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Skip to Search Results- 50Graduate and Postdoctoral Studies (GPS), Faculty of
- 50Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 15Chemistry, Department of
- 15Chemistry, Department of/Journal Articles (Chemistry)
- 2Agricultural, Food and Nutritional Science, Department of
- 2Agricultural, Food and Nutritional Science, Department of/Journal Articles (Agricultural, Food and Nutritional Science)
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2016
Han, Ling, Klassen, John S., Kitova, Elena N.
This study reports on the use of the catch-and-release electrospray ionization mass spectrometry (CaR-ESI-MS) assay, combined with glycomicelles, as a method for detecting specific interactions between water-soluble proteins and glycolipids (GLs) in aqueous solution. The B subunit homopentamers...
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Development and Application of Chemical Isotope Labeling Methods for Metabolomics Data Processing and Liquid Chromatography-Mass Spectrometry-Based Metabolomics
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Metabolomics is the study of chemical processes involving small-molecule metabolites in a given biological system. These small molecules are downstream outputs of cellular activities. An understanding of the metabolome change can help us to visualize perturbations in the genome or proteome from...
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Development and Application of ESI-MS Based Techniques for Quantitative Determination of Protein-Carbohydrate Interactions
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This thesis describes the development and application of mass spectrometry methods to study protein-ligand interactions in vitro. Liquid sample desorption electrospray ionization mass spectrometry (liquid sample DESI-MS) was employed to quantify protein-carbohydrate interactions in aqueous buffer...
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Development and application of mass spectrometry for bioanalysis of proteins and metabolites
DownloadSpring 2011
The proteome, a hybrid term from protein and genome, is the total set of proteins expressed by a genome in a cell, tissue, or organism at a given time. Proteomics, the study of the proteome, is concerned with a variety of topics such as identity, quantity, activity, structure, protein-protein...
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Development and Applications of Mass Spectrometric Methods for Proteome Analysis and Protein Sequence Characterization
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Mass spectrometry (MS) is widely used in proteomic work for protein identification and characterization. A key to the success of MS for protein analysis is related to sample preparation. Current sample preparation methods do not meet all the needs of protein or proteome analysis. My thesis work...
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Development and Applications of Stable Isotope Labelling Liquid Chromatography Mass Spectrometry for Quantitative Proteomics
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This thesis describes the characterization, automation, and applications of a stable isotope labelling method for quantitative proteomics by mass spectrometry. Known as 2MEGA, the method uses guanidinylation to convert peptide lysine residues to homoarginine followed by reductive methylation of...
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Development of Isotope Labeling Liquid Chromatography Mass Spectrometry for Biofluid Metabolomics and Applications in Disease Studies
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Metabolomics is a research field focusing on global study of all the metabolites present in a biological system (i.e., the metabolome). Metabolome analysis involves identifying and quantifying as many small molecule metabolites as possible in a biological sample. Metabolomics has attracted much...
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Development of isotope labeling liquid chromatography mass spectrometry for metabolome analysis
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As the endpoint of the “omics” cascade, metabolomics has attracted much attention in the discovery of diagnostic or prognostic disease biomarkers, and as a powerful tool to understand biological and biochemical processes and mechanisms. The objective of my research was to develop a highly...
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Development of Isotope Labeling Methods and Data Processing Program for Liquid Chromatography Mass Spectrometry-Based Metabolome Analysis
DownloadSpring 2014
Metabolomics strives to gain a comprehensive picture of the metabolites in a biological system. This emerging research field gives us an insight into the discovery of disease-related biomarkers and an understanding of metabolic flux as well as mechanisms. Liquid chromatography mass spectrometry...