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Skip to Search Results- 2Kinnaird, Adam
- 1Abdulsalam Alharbi
- 1Aktary, Zackie M
- 1Alolayan, Waad Riyad
- 1Alshamsan, Aws
- 1Amritpal Singh Bhullar
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Content Validity of a Questionnaire Specifically Designed to Clinically Identify Pediatric Environmental Exposures
DownloadSpring 2014
Various clinical questionnaires exist to assist clinicians with the diagnosis, prognosis, long-term follow up of a disease, or even to assess quality of life. However, any questionnaire must be evaluated for its validity and reliability before application. Invalid or unreliable questionnaires can...
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Deciphering the mechanism(s) which limit reovirus spread in resistant lung and HNSCC cancer cells
DownloadFall 2016
Reovirus is a naturally benign virus that preferentially replicates in transformed cells and is currently undergoing clinical trials as a promising oncolytic therapy. In normal mouse fibroblasts, transformation by constitutively activated Ras oncogene is sufficient to promote reovirus infection....
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Delivery of STAT3 inhibitor cucurbitacins to tumor by polymeric nano-carriers : Implications in cancer chemo- and immunotherapy
DownloadFall 2009
Signal Transducer and Activator of Transcription 3 (STAT3), a common oncogenic mediator, is constitutively activated in many types of human cancers and plays a critical role in tumor growth and cancer immune evasion. The focus of this dissertation is the delivery of STAT3 inhibitor cucurbitacins...
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Developing a Patient-Driven Arts-Based Knowledge Translation Tool for Parents of Children with Asthma
DownloadSpring 2016
Background: Family-centered education is critical to managing childhood asthma, the most common chronic disease of childhood in North America. Parents are largely responsible for the day-to-day management of their child’s asthma; as such, finding effective ways to educate parents about asthma is...
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Fall 2013
The aim of this work is to develop an effective non-viral carrier and to identify suitable gene targets that would induce apoptosis specifically in lymphoma cells upon down-regulation with short interfering RNA (siRNA). Lymphoma is common in children and young adults, and although survival rate...
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Development of block copolymer based nanocarriers for the solubilization and delivery of valspodar
DownloadFall 2011
One of the major causes of failure in cancer chemotherapy is multidrug resistance (MDR), where cancer cells become resistant to different types of anticancer drugs. Over-expression of membrane efflux pumps like P-glycoprotein (P-gp), which recognizes different chemotherapeutic agents and...
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Development of Genetic Medicines for the Treatment and Prevention of Infectious Disease, Cancer, and Aging
DownloadSpring 2022
Gene therapy has potential to become the Holy Grail of modern medicine, however, its clinical success has been hindered due to the lack of a safe and effective nucleic acid delivery platform. The recent success of non-viral RNA delivery platforms has revitalized the field and spurred great...
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Development of Novel Polymeric Micellar DACHPt for Enhanced Platinum Based Chemotherapy in Colorectal Cancer
DownloadSpring 2019
One of the major limitations of chemotherapy in cancer treatment is the side effects of anti-cancer drugs. This happens due to non-selective distribution of most standard chemotherapies, and their action on cancer and all normal dividing cells. The objective of this project is to develop a novel...
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Fall 2010
In many tumors, persistently-active signal transducer and activator of transcription 3 (STAT3) imparts several oncogenic features such as survival, proliferation, angiogenesis, and immune escape. Therefore, STAT3 targeting in cancer and cancer-exposed dendritic cells (DCs) is important for cancer...
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Fall 2014
Infant face and throat replicas are used in research laboratories to compare the effectiveness of different valved holding chamber and face mask designs. The use of soft face models is thought to provide a better representation of mask dead volume and face mask seal than hard face models....