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Skip to Search Results- 65Graduate and Postdoctoral Studies (GPS), Faculty of
- 65Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 12Roy Berg Kinsella Research Ranch
- 12Roy Berg Kinsella Research Ranch/Journal Articles (Kinsella Ranch)
- 9Agricultural, Food and Nutritional Science, Department of
- 9Agricultural, Food and Nutritional Science, Department of/Journal Articles (Agricultural, Food and Nutritional Science)
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Spring 2015
The tumor suppressor protein Ras association domain family 1A (RASSF1A) has roles in multiple signaling pathways including modulating apoptosis, the cell cycle, DNA damage, and microtubule organization. RASSF1A has been shown to be one of the most frequently epigenetically silenced genes in a...
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Fall 2013
Asphyxia is a significant cause of newborn morbidity and mortality. Multiorgan injury and dysfunction is a common finding, mediated in part through an increase in matrix metalloproteinase (MMP) activity. We hypothesized administration of doxycycline, a known MMP inhibitor, would improve systemic...
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Towards superior cancer drugs by modeling approaches: Modification and prediction of the mode of action
DownloadFall 2021
Cancer is a leading cause of death that imposes significant economic and social suffering on a global scale. Based on the projected growth and ageing of populations, the global burden of cancer is set to increase. Despite the vast investment in cancer research, the rate of translation of research...
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Transcriptome profiling of the small intestinal epithelium in germfree versus conventional piglets
Download2007
Beever, Jonathan E., Band, Mark R., Marini, Juan C., Schook, Lawrence B., Chowdhury, Shankar R., Rund, Laurie A., Willing, Benjamin P., Gaskins, H. Rex, King, Dale E., Loor, Juan J., Lane, Adrienne B., Van Kessel, Andrew G.
Background To gain insight into host-microbe interactions in a piglet model, a functional genomics approach was used to address the working hypothesis that transcriptionally regulated genes associated with promoting epithelial barrier function are activated as a defensive response to the...
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Transcriptomic and epigenetic profiling of the lung of influenza-infected pigs: A comparison of different birth weight and Susceptibility groups
Download2015-09-22
Harding, John C.S., Foxcroft, George R., Gunvaldsen, Rayna E., Dyck, Michael K., Plastow, Graham S., Detmer, Susan E., Wilkinson, Jamie M., Dixon, Walter T.
Influenza viruses are a common cause of respiratory disease in swine. Infections range in severity from asymptomatic to causing significant morbidity. The main objective of this study was to compare lung transcriptomic and epigenetic responses to influenza infection in pigs from high or low birth...
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Unveiling the pathway for the nuclear translocation of the large mitochondrial enzyme Pyruvate Dehydrogenase Complex (PDC)
DownloadSpring 2021
Pyruvate dehydrogenase complex (PDC) is a mitochondrial enzyme that links glycolysis to oxidative phosphorylation by decarboxylating glucose-derived pyruvate to produce acetyl-CoA that is used in the Krebs cycle. PDC was initially thought to reside only in the mitochondrial matrix but we recently...
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Variation in Fetal Outcome, Viral Load and ORF5 Sequence Mutations in a Large Scale Study of Phenotypic Responses to Late Gestation Exposure to Type 2 Porcine Reproductive and Respiratory Syndrome Virus
Download2014
Plastow, G., Lunney, J. K., Ladinig, A., Ashley, C., Detmer, S. E., Wilkinson, A., Harding, J. C. S.
In spite of extensive research, the mechanisms of reproductive disease associated with Porcine Reproductive and Respiratory Syndrome virus (PRRSv) are still poorly understood. The objectives of this large scale study were to evaluate associations between viral load and fetal preservation,...
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Variation in time and magnitude of immune response and viremia in experimental challenges with Porcine circovirus 2b
Download2014
Burkey, T., Engle, T., Davis, E., Moural, T., Ciobanu, D., McKnite, A., Barnes, S., Bundy, J., Jobman, E., Plastow, G, Kachman, S., Galeota, J.
© 2014 Engle et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the...
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Fall 2013
Cardiovascular dysfunction in asphyxiated neonates leads to significant morbidity and mortality and the hemodynamic support is limited to the use of catecholamines. In a pilot study, we showed that low-dose vasopressin improved myocardial tissue lactate levels, suggesting decreased anaerobic...
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Versatile Polymer-Based Nanomedicines for Drug/Gene Delivery and Cell-based Therapy Applications
DownloadSpring 2021
Advances in polymer science and nanotechnology have allowed the development of biomaterials for cell-based applications, such as the delivery of a variety of drugs and genes, as well as supporting technologies, such as stem cell therapies, tissue engineering and cryopreservation. The progress in...