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Skip to Search Results- 2Kinnaird, Adam
- 1Abdulsalam Alharbi
- 1Akhnokh, Maria Kodsy
- 1Aktary, Zackie M
- 1Al Lawati, Hanan M
- 1Alolayan, Waad Riyad
- 14Faculty of Pharmacy and Pharmaceutical Sciences
- 13Department of Agricultural, Food, and Nutritional Science
- 11Department of Medicine
- 10Department of Oncology
- 5Centre for Neuroscience
- 5Department of Biochemistry
- 3Lavasanifar, Afsaneh (Faculty of Pharmacy and Pharmaceutical Sciences)
- 3Michelakis, Evangelos (Medicine)
- 2Foley, Edan (Medical Microbiology and Immunology)
- 2Jamali, Fakhreddin (Faculty of Pharmacy and Pharmaceutical Sciences)
- 2Kerr, Bradley (Anesthesiology and Pain Medicine)
- 2Lemire, Bernard (Biochemistry)
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Evaluation of Hypoxia Induced Regulation of Nucleoside and Amino Acid Membrane Transporters in Breast Cancer
DownloadSpring 2020
Positron Emission Tomography (PET) utilizes radioactively tagged molecules to identify cancerous tissue. In most cases, membrane transporters control entry of these molecules into human cancer cells. Hypoxia-inducible factor (HIF)-1 is the master homeostatic regulator during hypoxia in human...
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Spring 2019
Energy expenditure forms the basis of all dietary recommendations. In patients with cancer, resting energy expenditure (REE) can be impacted by tumor burden, high systemic inflammation, and/or altered body composition. Total energy expenditure (TEE) and physical activity levels (PAL) have been...
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Fall 2020
Background: A standard treatment option for locally advanced rectal cancer includes 5-6 weeks of neoadjuvant chemoradiation (NACRT) followed by surgery about 6-8 weeks later. NACRT improves outcomes for rectal cancer patients but also causes acute toxicities which may impede quality of life...
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Exploring Novel Therapies for Motor and Non-Motor Symptoms in a Mouse Model of Multiple Sclerosis
DownloadSpring 2016
Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system characterized by neurodegeneration, inflammation and demyelination. Symptoms of multiple sclerosis not only include motor deficits, but also secondary symptoms of pain, depression and anxiety. The purpose of...
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Feeding high oleic acid Canola oil or olive oil alters inflammation, insulin resistance and lipid metabolism in a rodent model of diet induced obesity
DownloadFall 2011
To determine the efficacy of feeding monounsaturated fatty acids (MUFA) via a high MUFA Canola oil on T2D risk factors diet induced obese rats were fed either a low fat diet (LF), a high fat low MUFA diet (HF), a high fat high MUFA olive oil diet (OO), or a high fat high MUFA Canola oil diet...
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Food intake behaviour in advanced cancer – implications of taste and smell alterations, orosensory reward, and cannabinoid therapy
DownloadFall 2009
Food intake is regulated by both appetite and orosensory reward systems. Appetite systems stimulate or reduce hunger, while orosensory reward motivates consumption of high fat sweet foods, resulting in food enjoyment. The majority of advanced cancer patients suffer from malnutrition and wasting,...
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Fall 2013
Deregulated TNF signaling with elevated or decreased levels of TNF-induced apoptosis causes numerous inflammatory and cancerous diseases. Thus, there is a clear need to identify cellular proteins that regulate cell fate in the presence of TNF. RNA interference technology provides an excellent...
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Identifying Major Depressive Symptoms and Major Depressive Episodes in Adolescents with Cancer
DownloadFall 2015
Cancer is the leading cause of death from disease among adolescents in Canada. Although cancer is a well-researched disease process in the medical and nursing literature, adolescence is relatively understudied, with minimal evidence on strategies to promote healthy emotional adjustment...
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Imag(in)ing the cancerous body: representations of cancer in medical discourse and contemporary visual art
DownloadFall 2010
This thesis examines representations of cancer in contemporary art, with a particular focus on unruly, un-idealized bodies at risk. In bringing together the discourses of art history and medicine, its aim is to engage conventions of visualizing cancer, and more importantly, to highlight the ways...
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Spring 2023
The purpose of this dissertation was to explore, identify and address gaps in exercise oncology evidence-based care for individuals with cancer, with a specific focus on implementation of cancer-specific exercise programming. Further understanding is needed regarding the poor rates of reported...