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Skip to Search Results- 2Kinnaird, Adam
- 1Abdulsalam Alharbi
- 1Akhnokh, Maria Kodsy
- 1Aktary, Zackie M
- 1Al Lawati, Hanan M
- 1Alolayan, Waad Riyad
- 16Faculty of Pharmacy and Pharmaceutical Sciences
- 15Department of Agricultural, Food, and Nutritional Science
- 12Department of Medicine
- 10Department of Oncology
- 6Department of Biological Sciences
- 5Centre for Neuroscience
- 3Lavasanifar, Afsaneh (Faculty of Pharmacy and Pharmaceutical Sciences)
- 3Michelakis, Evangelos (Medicine)
- 2Baker, Glen (Psychiatry)
- 2Foley, Edan (Medical Microbiology and Immunology)
- 2Jamali, Fakhreddin (Faculty of Pharmacy and Pharmaceutical Sciences)
- 2Kerr, Bradley (Anesthesiology and Pain Medicine)
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Fall 2014
Infection with herpes simplex virus type 1 (HSV-1) leads to the rapid and complete loss of mitochondrial DNA (mtDNA) and mitochondrial messenger RNA (mt-mRNA), effectively eliminating gene expression within mitochondria. Previous work determined that a unique 3’ co-terminal transcript arising...
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Spring 2020
The human neuraminidases (NEU1, NEU2, NEU3, and NEU4) are a family of enzymes implicated in pathologies including cancer and diabetes. Our group has developed selective inhibitors for these enzymes that have been employed as tools to understand their biological roles. Several reports have linked...
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Fall 2013
Plakoglobin (γ-catenin) is a member of the Armadillo family of proteins and a homolog of β-catenin with similar dual adhesive and signaling functions. The adhesive function of these proteins is mediated by their interactions with cadherins and their signaling function by association with various...
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Molecular imaging of cyclooxygenase-2 (COX-2) and autotaxin (ATX) in cancer using positron emission tomography (PET)
DownloadFall 2020
Positron emission tomography (PET) relies on the use of β+-emitting radionuclide-bearing molecules congregating and decaying at a specific site of interest. Use of these molecules, called radiotracers, which target common tumor characteristics has become a pillar in the diagnosis of cancer and...
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Muscle Abnormalities in cancer patients: Exploring the biological characteristics of skeletal muscle of cancer patients
DownloadFall 2019
Computed tomography-derived muscle measures of sarcopenia and low muscle radiodensity have been associated with poor outcomes in cancer patients, however, the biological characteristics of the muscle in this population are not well understood. This research was conducted to first evaluate muscle...
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Myeloperoxidase-mediated bio-activation of NSAIDs in leukemia cells: Potential selective cytotoxicity
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Several lines of evidence have pointed to the potential benefit of anti-inflammatory drugs (NSAIDs) in cancer therapy due to the well-established correlation between cancer and chronic inflammation. Acute myeloid leukemia (AML) cells overexpress myeloperoxidase (MPO), which has been studied for...
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Fall 2016
Macrophages are the primary cells of innate immunity that provide the first line of defence against any external stimuli. Their phagocytic properties enable them to engulf invading microbes or foreign particles. The phagocytic capability of macrophages plays a major role in interfering with drug...
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New Insight into the Role of Myocardial Fatty Acid Uptake and Utilization in Health and Disease
DownloadFall 2013
All mammalian cells rely on adenosine triphosphate (ATP) to maintain function and for survival. The heart has the highest basal ATP demand of any organ due to the necessity for continuous contraction. As such, the ability of the cardiomyocyte to monitor cellular energy status and adapt the supply...
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Nutritional Factors Impacting Intestinal Lipid Metabolism Using a Model of Low Birth Weight Swine
DownloadSpring 2018
Introduction: Non-communicable diseases (NCDs) such as obesity, type 2 diabetes (T2D) and cardiovascular disease (CVD) are increasing at an alarming rate globally. A common feature in these conditions is increased adiposity leading to insulin resistance (IR). Dyslipidemia is a major contributing...