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Skip to Search Results- 65Graduate and Postdoctoral Studies (GPS), Faculty of
- 65Graduate and Postdoctoral Studies (GPS), Faculty of /Theses and Dissertations
- 6Agricultural, Food and Nutritional Science, Department of
- 6Agricultural, Food and Nutritional Science, Department of/Journal Articles (Agricultural, Food and Nutritional Science)
- 4CANHelp Working Group
- 4CANHelp Working Group/Journal Articles (CANHelp Working Group)
- 11Department of Agricultural, Food, and Nutritional Science
- 9Department of Oncology
- 6Faculty of Pharmacy and Pharmaceutical Sciences
- 4Department of Medicine
- 3Department of Pharmacology
- 3Faculty of Nursing
- 3Lavasanifar, Afsaneh (Faculty of Pharmacy and Pharmaceutical Sciences)
- 2McNeely, Margaret (Rehabilitation Medicine)
- 2Uludag, Hasan (Chemical and Materials Engineering)
- 1Alasdair Syme (Oncology)
- 1Ambrose, Divakar (Department of Agricultural, Food and Nutritional Science)
- 1Backhouse, Christopher J. (Electrical and Computer Engineering)
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Regulation of Anti-tumor Immunity in Colorectal Cancer by Interaction of Exosome Immune Complexes with Fc gamma Receptors
DownloadSpring 2019
Targeted therapy is difficult for colorectal cancer (CRC) due to lack of conserved tumor associated antigens (TAA). Immunotherapies for CRC directed at TAA that can overcome intestinal tolerance need to be developed to improve survival of CRC patients. Exosomes are extracellular vesicles secreted...
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A Multi-perspective Concept Mapping Study of Head and Neck Cancer Treatment Outcome Priorities
DownloadFall 2020
Background Head and neck cancer treatments have been showing promising outcomes, yet they often have significant impact on patients. With an approximate 50% survival rate, individuals with a history of this type of cancer are living with long term challenges. With the increasing focus on...
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A Pan Canadian Practice Guideline for Screening, Assessment, and Management of Cancer-Related Fatigue in Adults (Version 2)
Download2015-01-01
Howell, Doris, Keshavarz, Homa, Broadfield, Larry, Hack, Tom, Hamel, Marc, Harth, Tamara, Jones, Jennifer, McLeod, Deborah, Olson, Karin, Phan, Stephanie, Sawka, Annie, Swinton, Nelda, Ali, Muhammad U.
Background Cancer-related fatigue (CRF) is a prevalent problem in cancer and has a side effect of treatment that often worsens during cancer treatment and can persist as a long-term problem for many patients including those in palliative care and cancer survivor populations. Reported prevalence...
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Spring 2013
Polycomb protein methyltransferase, Enhancer of Zeste 2 (Ezh2), is frequently overexpressed in human malignancy and is implicated in cancer cell proliferation and invasion. Recently, several other polycomb proteins have been implicated in modulating the response to DNA double strand breaks, and...
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Fall 2015
DNA is a detailed layout of instructions for cellular function. The integrity of human DNA is constantly challenged by a barrage of exogenous and endogenous sources. A regime of genome stability maintenance has evolved to repair the many different types of DNA damage. A form of communication...
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2014
van Zanten, S.V., Chang, H.J., Morse, A., Lefebvre, M., Goodman, K.J.
Introduction. Helicobacter pylori infection is an emerging health concern to some northern Canadian Aboriginal communities and their clinicians. Clinicians in the north perceive H. pylori infection to be a major clinical problem because they find H. pylori infection in many patients evaluated for...
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Adiposity and fat loss in cancer: Exploring the prognostic significance and underlying mechanisms of adipose alterations in cancer
DownloadSpring 2017
During cancer progression, many patients will experience some degree of wasting of both muscle and adipose tissue. However, little is-known about adipose tissue alterations after a cancer diagnosis. Therefore, this research was conducted to first understand the prognostic significance of adipose...
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Anti-Cancer Mechanism of Trastuzumab via Blocking Nuclear HER2 Function and Epigenetic Mechanism of Resistance
DownloadSpring 2020
HER2 receptor tyrosine kinase (encoded by ERBB2 gene) is overexpressed in approximately 25% of all breast cancer tumors (known as HER2-positive breast cancers). Overexpression of HER2 causes overactivation of downstream receptor tyrosine kinase pathways including PI3K/Akt and MAPK pathways and is...
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Fall 2009
There is substantial evidence of the elevated risk of cancer among individuals with type 2 diabetes. Very little is known, however, about the role that antidiabetic therapies play in this relationship. The objective of this program of research was to examine whether there is a therapeutic risk...