Search
Skip to Search Results- 9Arachidonic acid
- 5Dietary intake
- 4Docosahexaenoic acid
- 3Cardiac hypertrophy
- 2Breast milk
- 2Cytochrome P450
- 1Aghazadeh Habashi, Ali
- 1Al Lawati, Hanan M
- 1Al-Thobaity, Najla'a
- 1Alsaad,Abdulaziz M
- 1Beaulieu, Michael J.
- 1Douglas, Claire
- 3Field, Catherine (Agricultural, Food and Nutritional Science)
- 1Anna Farmer (Department of Agricultural, Food and Nutritional Science and the Centre for Health Promotion Studies)
- 1Brocks, Dion (Pharmacy and Pharmaceutical Sciences)
- 1Dr. Ayman El-Kadi
- 1El-Kadi, Ayman (Faculty of pharmacy and pharmaceutical sciences)
- 1El-Kadi, Ayman (Pharmacy and Pharmaceutical Sciences)
-
The role of cytochrome P450 derived arachidonic acid metabolites against Angiotensin II-induced cardiac hypertrophy in Sprague Dawley rats and the RL-14 cell line
DownloadFall 2015
Several cytochrome P450 (CYP) enzymes and their arachidonic acid (AA) metabolites play essential roles in the maintenance of cardiovascular health, and their alteration gives rise to a number of cardiovascular diseases, including cardiac hypertrophy and heart failure. Recent data demonstrated...
-
Role of CYP-mediated Arachidonic Acid Metabolites in Development of Cardiac Hypertrophy and Chronic Doxorubicin-induced Cardiotoxicity
DownloadSpring 2013
Drug-induced cardiotoxicity is classified as a predisposing factor leading to cardiac hypertrophy and heart failure. Of importance, doxorubicin (DOX, adriamycin) is considered as an effective anticancer agent whose major limiting side effect is cardiotoxicity. Of importance, several studies...
-
Quality of Life, Exercise Behaviour and Baseline Dietary Intake of Women Undergoing Neoadjuvant Chemotherapy in the DHA WIN Randomized Controlled Trial
DownloadSpring 2024
Breast cancer is the second most common cancer in Canada. It is estimated that one in eight Canadian women will be diagnosed with the disease in their lifetime. Neoadjuvant chemotherapy is often prescribed to improve surgical resection outcomes and reduce micrometastases. Achieving a pathological...
-
MODULATING CYTOCHROME P450-MEDIATED ARACHIDONIC ACID METABOLISM AS A POTENTIAL NEW TREATMENT MODALITY FOR CARDIAC HYPERTROPHY
DownloadSpring 2017
El-Sherbeni, Ahmed Abd El-Hakeem
Arachidonic acid (AA) metabolism has long been a very appealing target for drug discovery and development efforts. Beside cyclooxygenase and lipoxygenase pathways, AA is also metabolized by the recently recognized cytochrome P450 (P450) pathway, forming several biologically-active...
-
Fall 2012
Malignant gliomas (MG) are the most common and aggressive brain cancers. FABP7 is an intracellular lipid trafficking molecule whose expression correlates with reduced MG patient survival. FABP7 has been shown to increase the migratory behaviour of MG cells. Moreover, the migratory behaviour of...
-
Maternal Essential Fatty Acid Status During Pregnancy and Postpartum in the Alberta Pregnancy Outcomes and Nutrition (APrON) Study and Infant Outcomes
DownloadSpring 2017
Docosahexaenoic (DHA) and arachidonic (AA) acids are essential fatty acids found in breast milk and are important for the infant’s brain development and cognitive functions such as those that regulate sleep and crying. The overall goal of this research was to use a large maternal infant cohort,...
-
Influence of lipids (arachidonic acid and cholesterol) on calcium signalling in rodent pancreatic beta cells
DownloadFall 2010
Ca2+ is an important mediator of stimulus-secretion coupling in beta cells of the pancreatic islets, which secrete insulin in response to elevation in plasma glucose concentration. I studied the actions of two lipids, arachidonic acid (AA) and cholesterol, on enzymatically-dissociated single...
-
Glucosamine Anti-Inflammatory Dose-Effect Correlation and Its Influence on the Renin-Angiotensin System Components and Arachidonic Acid Metabolites under Inflammatory Condition in the Rat with Adjuvant Arthritis
DownloadSpring 2015
Crystalline glucosamine (GlcN) sulfate salt formulation is approved as a prescription drug with anti-inflammatory effects for the management of osteoarthritis (OA) in the European Union, while it is considered as a nutraceutical in North America. The effectiveness of GlcN for ameliorating the...
-
Fall 2016
Choline is an essential micronutrient with increased requirements during pregnancy and lactation due to a high demand by the developing fetus and infant. Animal studies have demonstrated that choline is essential for brain development, and as a component of all cell membranes it is hypothesized...
-
Evaluating the effects of dietary docosahexaenoic acid along with arachidonic acid during the development of the immune system in early life.
DownloadSpring 2023
The immune system is immature at birth and the dietary fats provided during early life play an important role in the development of the infant’s immune system. The precursor omega-3 (n-3) and n-6 polyunsaturated fatty acids (PUFAs) α-linolenic acid and linoleic acids, respectively, are essential...