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Skip to Search Results- 2Kinnaird, Adam
- 1Abdulsalam Alharbi
- 1Akhnokh, Maria Kodsy
- 1Aktary, Zackie M
- 1Al Onazi, Mona Moraybed
- 1Alolayan, Waad Riyad
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Deciphering the mechanism(s) which limit reovirus spread in resistant lung and HNSCC cancer cells
DownloadFall 2016
Reovirus is a naturally benign virus that preferentially replicates in transformed cells and is currently undergoing clinical trials as a promising oncolytic therapy. In normal mouse fibroblasts, transformation by constitutively activated Ras oncogene is sufficient to promote reovirus infection....
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Decongestive Progressive Resistance Exercise with Advanced Compression for Breast Cancer Related Lymphedema Management (DREAM): A Pilot Randomized Control Trial
DownloadFall 2018
Introduction: More than one in five women who survive breast cancer will eventually develop lymphedema. Recent studies in breast cancer lymphedema management have demonstrated that resistance exercise can improve the survivors’ quality of life without exacerbating their lymphedema. However,...
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Delivery of STAT3 inhibitor cucurbitacins to tumor by polymeric nano-carriers : Implications in cancer chemo- and immunotherapy
DownloadFall 2009
Signal Transducer and Activator of Transcription 3 (STAT3), a common oncogenic mediator, is constitutively activated in many types of human cancers and plays a critical role in tumor growth and cancer immune evasion. The focus of this dissertation is the delivery of STAT3 inhibitor cucurbitacins...
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Development and Applications of Quantitative Mass Spectrometric Methods for Proteome and Protein Analysis
DownloadSpring 2013
Quantitative proteomics has been increasingly recognized as a key research topic in proteomics research, as it enumerates changes of proteins’ expression level in a bio-system. Quantitative proteomics provides an important way to discover biomarkers for disease diagnosis and prognosis, and also...
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Development of A Gadolinium-Based Nanotheranostics Platform for Irradiation Activatable MRI-Radiosensitization and Doxorubicin Release in Cancer Therapy
DownloadSpring 2022
The ultimate goal of this thesis research was to design, fabricate, and characterize an integrated nanotheranostics platform for activatable doxorubicin delivery and simultaneous MRI- radiosensitization for synergistic cancer therapy, targeting breast cancer treatment. As shown in the diagram,...
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Fall 2013
The aim of this work is to develop an effective non-viral carrier and to identify suitable gene targets that would induce apoptosis specifically in lymphoma cells upon down-regulation with short interfering RNA (siRNA). Lymphoma is common in children and young adults, and although survival rate...
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Development of a Targeted Adenoviral Vector Expressing HSV-TK for use in Breast Cancer Gene Therapy and Analysis through Positron Emission Tomography
DownloadFall 2012
While adenoviral (Ad) vectors are the most commonly used gene delivery vector for human gene therapy, improvements must be made to increase Ad specificity to tumors if they are to be used for cancer gene therapy. Our goal is to target adenoviral vectors to breast cancer (BrCa) cells to induce...
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Development of block copolymer based nanocarriers for the solubilization and delivery of valspodar
DownloadFall 2011
One of the major causes of failure in cancer chemotherapy is multidrug resistance (MDR), where cancer cells become resistant to different types of anticancer drugs. Over-expression of membrane efflux pumps like P-glycoprotein (P-gp), which recognizes different chemotherapeutic agents and...
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Development of Genetic Medicines for the Treatment and Prevention of Infectious Disease, Cancer, and Aging
DownloadSpring 2022
Gene therapy has potential to become the Holy Grail of modern medicine, however, its clinical success has been hindered due to the lack of a safe and effective nucleic acid delivery platform. The recent success of non-viral RNA delivery platforms has revitalized the field and spurred great...
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Development of novel compounds for the molecular imaging of hypoxia: 18F-labeled nitroimidazoles and hypoxia inducible factor 1 alpha (HIF-1a)-targeting compounds
DownloadSpring 2023
Imaging of hypoxia has been previously achieved using positron emission tomography (PET) with radiotracers such as [18F]fluoroazomycin arabinoside ([18F]FAZA) [1] or [18F]fluoromisonidazole ([18F]FMISO) [2]. These typical nitroimidazole containing compounds are reductively trapped in hypoxic...