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Skip to Search Results- 1Alyenbaawi, Hadeel Eb
- 1Barber, Quinn
- 1Bernier, Ashlyn
- 1Champion, Claudine C.
- 1DeSilva, Alan D
- 1Effa, Corrie Joelle
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Giving Voice to the Unheard: Perceptions, Practices & Beliefs About Breast Cancer and Screening Among Ethnic Minority Women From the MENA (Middle East & North Africa) Region in Edmonton, Alberta.
DownloadFall 2019
Breast cancer is one of the major causes of death among women in Canada and globally. In Canada, screening has been found to be successful in decreasing morbidity and mortality (Canadian Cancer Society, 2015). Use of breast cancer screening services by immigrant women however is limited...
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Restoring Body Image after Breast Cancer through Exercise and Art Sculpture “RISE UP” after Breast Cancer: A Pilot Multi-Methods Study
DownloadFall 2020
The purpose of this thesis was to explore and describe body image in survivors of breast cancer in the context of supportive care, with specific focus on resistance exercise training and art therapy. The overall purpose of this work was to inform current practice and offer an alternative approach...
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A Novel Comparative Analysis Approach to Personalize Chemotherapy Dose Calculation in Early Breast Cancer
DownloadFall 2018
Background Worldwide, body surface area [BSA] is used to calculate chemotherapy dose. The BSA formula was originally developed in 1916, derived from height and weight, with no consideration of other patient characteristics. Most chemotherapy agents have a narrow therapeutic index and are...
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Assessing the Feasibility of Learning Biomedical Phenotype Patterns Using High-Throughput Omics Profiles
DownloadSpring 2014
A decade after the completion of the human genome project, the rapid advancement of the high-throughput measurement technologies has made omics (genomics, epigenomics, transcriptomics, metabolomics) profiling feasible. The availability of such omics profiles has raised the hope for the...
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Binding, internalization, and transgene expression of an adenoviral vector retargeted to HER3/4
DownloadFall 2013
Adenoviruses (Ads) have been well studied for use in cancer gene therapy. However, low levels of the primary receptor, coxsackie-adenovirus receptor (CAR), in tumor cells has been shown to be a factor in low transgene expression. To increase Ad infection of breast cancer cells we constructed a...
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Fall 2014
Fungal pathogens are recognized by Dectin-1, a pattern recognition receptor expressed on mammalian innate immune cells. Dectin-1 detects β-glucans, which are polymers of glucose that are a main component of the fungal cell wall. While purified, soluble β-glucans have been used in the clinic as...
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Development of A Gadolinium-Based Nanotheranostics Platform for Irradiation Activatable MRI-Radiosensitization and Doxorubicin Release in Cancer Therapy
DownloadSpring 2022
The ultimate goal of this thesis research was to design, fabricate, and characterize an integrated nanotheranostics platform for activatable doxorubicin delivery and simultaneous MRI- radiosensitization for synergistic cancer therapy, targeting breast cancer treatment. As shown in the diagram,...
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Development of a Targeted Adenoviral Vector Expressing HSV-TK for use in Breast Cancer Gene Therapy and Analysis through Positron Emission Tomography
DownloadFall 2012
While adenoviral (Ad) vectors are the most commonly used gene delivery vector for human gene therapy, improvements must be made to increase Ad specificity to tumors if they are to be used for cancer gene therapy. Our goal is to target adenoviral vectors to breast cancer (BrCa) cells to induce...
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Fall 2017
For cancer research, a powerful imaging modality for both preclinical (where the focus is on imaging small animals) and clinical (where the focus is on imaging human subjects) applications should be inexpensive, portable, noninvasive, safe, and capable of measuring a myriad of information....
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Drug Resistance in Breast Cancer: Characterization of Rationally Designed Paclitaxel Analogs in Model Systems
DownloadFall 2013
Breast cancer is a leading cause of cancer related deaths among women in the developed world. Treatment options for breast cancer include taxanes, which mediate cytotoxic effects by inducing microtubule polymerization which impedes cell division. Taxane resistant breast cancer is a mounting...