Search
Skip to Search Results- 1Alsaikhan, Bader H
- 1Araya, Luam Ellen
- 1Baghdasarian, Argishti
- 1Brennan, Lesley Jean
- 1Chan, Calvin J
- 1Chaurasiya, Shyambabu
-
Novel Agents Inhibiting Hepatitis C Virus; Application to Prevention of Re-infection after Liver Transplantation
DownloadFall 2013
Recurrent Hepatitis C virus infection drives inferior outcomes experienced by patients undergoing liver transplantation due to HCV-associated liver disease. Existing therapies exhibit increased toxicity, poor efficacy, and profound patient intolerability in the immediate transplantation period....
-
Spring 2017
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), continues to be a leading infectious cause of death worldwide with approximately 10 million new cases and 2 million deaths attributed annually. There has been resurgence in active TB infections since 1980s and the World Health...
-
Proteomic analysis of wheat (Triticum aestivum) whole roots and cell walls under water-deficit stress
DownloadSpring 2011
Wheat plants are affected by water-deficit stress in various regions of the world resulting in reduced crop productivity and thus decreased food production. To better understand the protein changes of water-deficit stress in wheat roots, comparative proteomics was performed using 2D gel...
-
The Proteome of Partial Bladder Outlet Obstruction & The Therapeutic Role of Mesenchymal Stem Cells
DownloadFall 2013
Introduction: Partial bladder outlet obstruction (pBOO) is a common problem in urology. It passes through several pathological phases before progressing to bladder fibrosis. Herein, we investigated the proteomic profile of the urinary bladder in the early phase after pBOO, and examined the...
-
Unique cellular interactions between the obligate intracellular bacteria Wolbachia pipientis and its insect host
DownloadFall 2011
Wolbachia are maternally inherited obligate intracellular bacteria found in arthropods, where they induce feminization, male-killing, parthenogenesis, and cytoplasmic incompatibility (CI). CI is conditional male sterility, in which Wolbachia-infected males successfully mate with infected females,...
-
Fall 2014
Smallpox was eradicated using vaccinia viruses (VACV) as vaccines, including Dryvax, a calf-lymph vaccine derived from the New York City Board of Health (NYCBH) strain, and TianTan, a chicken egg cultured vaccine used exclusively in China. To take advantage of the next generation sequencing...
-
Vaccinia virus DNA polymerase and ribonucleotide reductase: their role in replication, recombination and drug resistance
DownloadSpring 2010
Despite the eradication of smallpox, poxviruses continue to cause human disease around the world. At the core of poxvirus replication is the efficient and accurate synthesis and repair of the viral genome. The viral DNA polymerase is critical for these processes. Acyclic nucleoside phosphonate...
-
Fall 2021
Poxviruses encode many genes that are orthologs of cellular genes. These orthologs serve many functions, but those that are of most interest are ones that have evolved further and now serve an immune-evasion function. Such genes were likely first acquired by poxviruses through some form of...
-
Fall 2016
Breast cancer (BrCa) is the most common cancer and the leading cause of cancer-related deaths in women worldwide. Current therapies for BrCa are insufficient to cure metastatic disease and are often associated with debilitating side effects that severely deteriorate the quality of patients’...