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Spring 2021
Splicing is an essential step in the post-transcriptional modification of pre-mRNAs in eukaryotes. This process is catalyzed by the spliceosome, a multi-megadalton nuclear protein-RNA enzyme which excises non-coding sequence from RNA transcripts prior to translation. Deficient or improper...
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Combined Adsorption and Biodegradation Processes for Oil Sands Process-Affected Water Treatment
DownloadFall 2014
The oil sands process-affected water (OSPW) generated from bitumen extraction of oil sands by industries in Northern Alberta, Canada, is a great environmental concern because of the OSPW toxicity in the environment. This toxicity has been attributed to a group of alicyclic and aliphatic compounds...
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Fall 2014
The oil sands landscape in northern Alberta is interspersed with large tailings ponds that hold wastewater from bitumen mining and extraction processes. Recent monitoring results indicate that annually many thousands of birds, mostly migrating waterfowl, land on the ponds associated with this...
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Spring 2020
Calcium homeostasis is essential and central to a variety of cellular processes from cell life and death pathways to metabolism to muscle contraction. One component that is essential to intracellular calcium regulation is known as the sarco(endo)plasmic reticulum Ca-ATPase, or SERCA. SERCA...
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Fall 2021
Caspases are a family of enzymes that regulate biological processes, such as inflammation and programmed cell death, through proteolysis. For example, in the intrinsic pathway of apoptosis, cell death signaling involves cytochrome c release from the mitochondria, which leads to the activation of...
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Pyranopterin Coordination Controls Molybdenum Electrochemistry in Escherichia coli Nitrate Reductase
DownloadFall 2015
Molybdenum is an essential trace element for most species on the earth. Molybdoenzymes (enzymes containing Molybdenum) play diverse roles in human health, global geochemical cycles, and bacterial metabolism. Interestingly, nitrate reductase (NarGHI) isolated from the common gut bacterium...
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Fall 2018
Protein kinases are critical players in cell signaling processes and their activity leads to the phosphorylation of substrates, often regulating enzymatic activity. 518 protein kinases are encoded in the human genome, however, there are many features within the catalytic domain of these proteins...
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Fall 2018
Desmosomes are large, complex protein assemblies which, at the most fundamental level, facilitate cellular adhesion. On a grander scale, desmosomes, and more specifically desmosomal networks, are critical for the maintenance of tissue integrity. They link the cytoskeletons of adjacent cells...
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Fall 2018
Chloride intracellular channel (CLIC) proteins comprise six members CLIC1–CLIC6 in mammals and mediate functions not fully known. Their founding member was isolated from bovine kidney using the chloride channel inhibitor indanyloxyacetic acid-94, so CLICs were assumed to be typical anion...