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2019-01-01

Chiu, Christine C., Keeling, Christopher I., Henderson, Hannah M., Bohlmann, Joerg

The mountain pine beetle (MPB; Dendroctonus ponderosae) is a forest insect pest that attacks several different pine (Pinus) species in its native range of distribution in western North America. MPB are exposed for most of their life cycle to the chemical defenses of their hosts. These defenses...

2006-02-02

Keeling, Christopher I., Bohlmann, Jörg

Insects select their hosts, but trees cannot select which herbivores will feed upon them. Thus, as long-lived stationary organisms, conifers must resist the onslaught of varying and multiple attackers over their lifetime. Arguably, the greatest threats to conifers are herbivorous insects and...

Fall 2012

Chaudhary, Ketul R

Ischemic heart disease remains a major cause of illness, disability and death worldwide, as such there remains a need for novel pharmacological agents that protect against myocardial ischemia reperfusion (I/R) injury. Epoxyeicosatrienoic acids (EETs) are cytochrome P450 (CYP) epoxygenase...

Spring 2017

El-Sherbeni, Ahmed Abd El-Hakeem

Arachidonic acid (AA) metabolism has long been a very appealing target for drug discovery and development efforts. Beside cyclooxygenase and lipoxygenase pathways, AA is also metabolized by the recently recognized cytochrome P450 (P450) pathway, forming several biologically-active...

Spring 2017

Elshenawy, Osama H. A.

Arsenic is a worldwide environmental pollutant that is associated with skin and several types of internal cancers, such as liver, lung, kidney, urinary bladder, and prostate cancers. Recent reports revealed that organic arsenic metabolites, such as trimethylarsine oxide (TMAO), dimethylarsinic...

Fall 2024

Elghiaty, Mahmoud AA

Arsenic trioxide (ATOIII) has evolved into a successful therapy for acute promyelocytic leukemia (APL), however, being an arsenical, it retains at its core the hypertoxic characteristics of that notorious metalloid. Such inherent toxicity causes a constellation of complications in APL patients,...

2011

Proctor, H. C., Evenden, M. L., Mori, B. A., Walter, D. E.

Abstract: We identified species of mites phoretically associated with mountain pine beetle, Dendroctonus ponderosae Hopkins (Coleoptera: Curculionidae: Scolytinae), collected from bolts of lodgepole pine, Pinus contorta Douglas ex Louden (Pinaceae), and pheromone-baited traps in northwestern...

2019-01-01

Erbilgin, Nadir

Mountain pine beetle (MPB, Dendroctonus ponderosae) has recently breached the geo-climatic barrier of the northern Rocky Mountains and invaded novel jack pine (Pinus banksiana) forests in western Canada. This breach signifies an unprecedented climate change-induced invasion of a new plant biome...

2019-01-01

Chiu, Christine C., Keeling, Christopher I., Bohlmann, Joerg

The recent outbreak of the mountain pine beetle (Dendroctonus ponderosae; MPB) has afected over 20M hectares of pine forests in western North America. During the colonization of host trees, female MPB release the aggregation pheromone (−)-trans-verbenol. (−)-trans-Verbenol is thought to...

Spring 2013

Tse, Mandy M.Y.

Cytochrome P450 (CYP) enzymes have been identified in the heart and their levels have been reported to be altered during cardiac hypertrophy and heart failure. Furthermore, CYP enzymes have been shown to metabolize arachidonic acid to cardioprotective epoxyeicosatrienoic acids (EETs) and...