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Arthritis in the Canadian Aboriginal population: north-south differences in prevalence and correlates
Download2010
Ng, Carmina, Chatwood, Susan, Young, T. Kue
"Background: Information on arthritis and other musculoskeletal disorders among Aboriginal people is sparse. Survey data show that arthritis and rheumatism are among the most commonly reported chronic conditions and their prevalence is higher than among non-Aboriginal people. Objective: To...
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2008-12-01
Kelly, Janet, Lanier, Anne, Santos, Maria, Healey, Sylvia, Louchini, Rabia, Friborg, Jeppe, Young, T. Kue
"Objectives: This is first of 2 papers on the Circumpolar Inuit Cancer Review, an international collaborative effort involving researchers and health officials from Alaska, Canada and Greenland. It covers the period 1989–2003, updating the last review (1969-1988) and together provides an overview...
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2008-12-01
Kelly, Janet, Lanier, Anne, Santos, Maria, Healey, Sylvia, Louchini, Rabia, Friborg, Jeppe, Young, T. Kue
"Objectives: This is the second of 2 papers reporting on the result of the Circumpolar Inuit Cancer Review, an international collaborative effort involving researchers and health officials from Alaska, Canada and Greenland. Methods: Inuit cancer cases by age-sex group and anatomic site were...
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Cardiovascular Risk According to Plasma Apolipoprotein and Lipid Profiles in a Canadian First Nation
Download2011
Riediger, Natalie D., Bruce, Sharon G., Young, T. Kue
"Introduction: Despite high diabetes rates among Canadian First Nations people, little is known about their cardiovascular disease risk. Our aim was to describe the apolipoprotein profile with respect to cardiovascular risk in a Canadian First Nation community. Methods: In 2003, a representative...
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Characteristics and prevalence of the metabolic syndrome among three ethnic groups in Canada
Download2005-11-22
Liu, Juan, Hanley, Anthony J. G., Young, T. Kue, Harris, S. B., Zinman, Bernard
"Objective: To compare the characteristics and prevalence of the metabolic syndrome (MetS) among Native Indians, Inuit, andnon-Aboriginal Canadians. Methods: The study was based on four cross-sectional studies conducted in the late 1980s and early 1990s involving threeethnic groups living in...
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2001-06-01
Hegele, Robert A., Huff, Murray W., Young, T. Kue
"We discovered that rare mutations in LMNA, which encodes lamins A and C, underlie autosomal dominant Dunnigan-type familial partial lipodystrophy. Because familial partial lipodystrophy is an extreme example of genetically disturbed adipocyte differentiation, it is possible that common variation...
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Common Low-Density Lipoprotein Receptor p.G116S Variant Has a Large Effect on Plasma Low-Density Lipoprotein Cholesterol in Circumpolar Inuit Populations
Download2014-11-20
Dubé, Joseph B., Wang, Jian, Cao, Henian, McIntyre, Adam D., Johansen, Christopher T., Hopkins, Scarlett E., Stringer, Randa, Hosseinzadeh, Siyavash, Kennedy, Brooke A., Ban, Matthew R., Young, T. Kue, Connelly, Philip W., Dewailly, Eric, Bjerregaard, Peter, Boyer, Bert B., Hegele, Robert A.
"Background: Inuit are considered to be vulnerable to cardiovascular disease because their lifestyles are becoming more Westernized. During sequence analysis of Inuit individuals at extremes of lipid traits, we identified 2 nonsynonymous variants in low-density lipoprotein receptor (LDLR), namely...
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Common variants APOC3, APOA5, APOE and PON1 are associated with variation in plasma lipoprotein traits in Greenlanders
Download2007-12-01
Lahiry, Piya, Ban, Matthew R., Pollex, Rebecca L., Sawyez, Cynthia G., Huff, Murray W., Young, T. Kue, Bjerregaard, Peter, Hegele, Robert A.
"Objectives: We undertook studies of the association between common genomic variations in APOC3, APOA5, APOE and PON1 genes and variation in biochemical phenotypes in a sample of Greenlanders. Study Design: Genetic association study of quantitative lipoprotein traits. Methods: In a sample of...
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Contributions to chronic disease prevention and control: studies among the Kivalliq Inuit since 1990
Download2003-12-01
"A population-based health interview and examination survey of 8 Inuit communities in the Kivalliq region of Nunavut, Canada, during the early 1990s has resulted in an increased understanding of the burden and extent of cardiovascular diseases and diabetes and their risk factors such as genetics,...
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Dietary correlates of an at-risk BMI among Inuit adults in the Canadian high arctic: cross-sectional international polar year Inuit health survey, 2007-2008
Download2012-09-18
Zienczuk, Natalia, Young, T. Kue, Cao, Zhirong R., Egeland, Grace M.
"Background: The study’s objective was to investigate the dietary correlates of an at-risk body mass index (BMI) among Inuit adults from thirty-six communities across the Canadian Arctic using data from the cross-sectional International Polar Year Inuit Health Survey, conducted in 2007–2008....