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Spring 2014
Lower-extremity peripheral artery disease (PAD) is a manifestation of atherosclerotic disease in the lower limbs. PAD is a risk factor for poor outcomes including myocardial infarction, stroke, and mortality. Despite the potential benefits of early PAD detection, in the majority of PAD cases...
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Diabetes in Pregnancy among First Nations Women in Alberta: A Multiphase Mixed Methods Approach
DownloadFall 2013
Background Diabetes in pregnancy is thought to be an important driver of the current epidemic of type 2 diabetes in First Nations populations. Purpose The purpose of this doctoral research was 1) to generate an epidemiological profile of First Nations diabetes in pregnancy in Alberta; and 2) to...
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Mapping intracellular cytokine pools in granulocytes: Dynamic storage and trafficking sites of interleukin-9 and interleukin-13 in human eosinophils
DownloadFall 2020
Eosinophils are immune cells with constantly evolving roles in both innate and adaptive immunity and have long been associated with the predominant pathology of the human airways, asthma. Eosinophils are specialized in their granulocytic nature, possessing several membrane-bound secretory...
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Respiratory Syncytial Virus infection biases the immune response in favor of Th2: the role of Indoleamine 2, 3-dioxygenase
DownloadSpring 2012
Infants that develop severe bronchiolitis due to Respiratory Syncytial Virus (RSV) are at increased risk of developing asthma later in life. To begin my studies in vitro, purified RSV stock was needed. My first study established the critical steps in RSV purification to determine a procedure that...
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The Epidemiology of Venous Thromboembolism in Alberta, Canada: A Population Based Cohort Study.
DownloadSpring 2016
Background: Venous thromboembolism (VTE), comprises both deep vein thrombosis (DVT) and pulmonary embolism (PE). It is a common acute cardiovascular event associated with increased long-term morbidity, disability, all-cause mortality, and high rates of recurrence. Major advances in diagnosis,...
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Fall 2014
Epidemiological studies correlate vitamin D deficiency with asthma severity. Calcitriol modulates receptor and cytokine expression from various leukocytes in an anti-inflammatory manner. Despite eosinophil activity during mucosal inflammation, knowledge on the direct effect of calcitriol on this...