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Skip to Search Results- 1Abd Elhafiz, Areeg
- 1Abeysundara, Namal W
- 1Anderson-Baron, Matthew N
- 1Androschuk, Alaura MA
- 1Arnold, Kirsten J
- 1Ayeni, Joseph O
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Genetic, genomic and molecular studies of signaling pathways controlling ecdysone biosynthesis in Drosophila melanogaster
DownloadFall 2013
In insects, periodic pulses of the molting hormone ecdysone control all major developmental transitions such as the molts and metamorphosis. Ecdysone, a steroid hormone, is produced in the prothoracic gland during larval and pupal development of Drosophila. While we have a relatively good...
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Spring 2024
To maintain an effective barrier, intestinal epithelial progenitor cells must divide at a rate that matches the loss of dead and dying cells. Epithelial damage during most enteric infection accelerates cell proliferation and tissue repair via multiple stress responses. However, infection with the...
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Spring 2019
Myt1 kinase performs several functions during Drosophila development. Myt1 has firstly been described as a regulator of the G2/M DNA damage checkpoint in the developing wing disc. In addition, Myt1 has been shown to regulate several aspects of male and female gametogenesis, while also...
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Investigating the Nuclear Roles of Iron Regulatory Protein-1A (IRP1A) in Drosophila melanogaster
DownloadFall 2023
Iron is an indispensable micronutrient for almost all organisms. Either the lack or excess of iron can result in various human diseases. Therefore, to maintain cellular iron homeostasis, the IRP/IRE (iron regulatory protein/iron responsive element) system tightly regulates iron concentrations....
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Fall 2022
The ppk20 (pickpocket 20) gene was identified from a two-step screen that was aimed at identifying genes relevant to Drosophila iron and heme homeostasis. Initially, our lab collaborated with two other labs and carried out a prothoracic gland (PG)-specific genome-wide screen of 12,500 RNA...
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Looking beyond the standard genome-wide association study: Biologically-motivated methodological approaches to discover novel genetic variants associated with complex human traits and disease
DownloadFall 2018
The standard approach for testing associations between common single nucleotide genetic variants (referred to as single nucleotide polymorphisms or SNPs) and disease entails testing disease associations for each SNP in the genome individually. This “hypothesis-free” approach has identified...
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Spring 2023
Intestinal epithelial damage and homeostatic cell shedding sends evolutionarily conserved growth signals to activate division programs in stem cells, which renews the epithelium to maintain barrier integrity. In addition to conserved growth and stress signaling, microbes and innate immune...
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Spring 2013
If all cells in a multicellular organism contain exactly the same genetic information, the question arises of how tissue types with distinct gene expression profiles are formed and maintained over the life of the organism. These different temporal and spatial gene expression patterns are thought...
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Fall 2020
Peroxisomes are organelles responsible for processing lipids and managing reactive oxygen species. A conserved family of genes called peroxisome biogenesis factors (Peroxin, Pex) encode proteins necessary for peroxisome biogenesis and function. In yeast and mammals, PEROXIN7 (PEX7) acts as a...
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Fall 2015
Malignant glioma (MG), comprised of grade III (anaplastic astrocytoma) and grade IV (glioblastoma) astrocytoma, is the most common adult brain tumour, with an incidence of ~4 in 100 000 people. Despite aggressive treatment with surgery, radiation, and chemotherapy, survival remains dismal, with...