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Skip to Search Results- 1Adam, Ibrahim S. Y.
- 1Akinwumi, Segun M
- 1Alford, Spencer Caleb
- 1Anbukarasu, Preetam
- 1Anderson, Sarah J
- 1Assempour, Nazanin
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Regulation of Anti-tumor Immunity in Colorectal Cancer by Interaction of Exosome Immune Complexes with Fc gamma Receptors
DownloadSpring 2019
Targeted therapy is difficult for colorectal cancer (CRC) due to lack of conserved tumor associated antigens (TAA). Immunotherapies for CRC directed at TAA that can overcome intestinal tolerance need to be developed to improve survival of CRC patients. Exosomes are extracellular vesicles secreted...
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A novel mouse model of acute antibody-mediated transplant rejection shows simultaneous complement activating and anti-inflammatory effects of donor specific IgG antibodies
DownloadFall 2013
We developed a small animal model of pure antibody-mediated rejection (ABMR) by utilizing fully major histocompatibility complex (MHC) mismatched kidney allografts in mice. By examining resultant ABMR pathology, we show that terminal complement products C5a and C5b-9 are crucial in establishing...
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Fall 2020
Introduction: ABO-incompatible organ transplants (ABOi-Tx) recipients are at high-risk of rapid rejection mediated by ABO antibodies (ABO Abs). To manage and expand ABOi-Tx, it is necessary to understand the mechanism(s) by which natural and induced ABO Abs develop. Prior studies have used...
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An Exploration of the Cost of Liver Transplantation Using the OrganOx Normothermic Machine Perfusion in Comparison to Static Cold Storage in the Canadian Setting
DownloadFall 2021
Liver transplantation is life-saving but costly for the health care system, the patient and their caregivers. Over the last decade there has been a decrease in the available liver grafts leading to an increased use of extended criteria donors and an increase in the waitlist mortality rate. The...
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An examination of linking and blocking procedures for use in deflection cantilever array-based protein detection
DownloadFall 2011
In this project common linking and blocking procedures were examined for use in multiplexed deflection cantilever array-based detection of proteins. A human interferon gamma (INF-γ) enzyme-linked immunosorbent assay (ELISA) kit was used to evaluate the effectiveness of the linking and blocking...
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Fall 2014
Carbohydrate–protein interactions play key roles in a range of biological processes. Noticeable advancements have been made in understanding the features associated with the recognition of pyranosides (six-membered ring sugars) by proteins. In contrast, similar detailed studies about the...
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Carbon-on-Gold Films and Spontaneous Adsorption of Aryldiazonium Salts for Surface Plasmon Resonance Sensing
DownloadFall 2021
Over the past decades, surface plasmon resonance (SPR) technology has gained popularity as a powerful analytical technique for the study of biomolecular interactions and medical diagnostics. This is made possible thanks to the well-established gold-thiolate chemistry. However, the limited...
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Characterization of Binding of LILRA3 and LILRB2 to the Myelin-Associated Inhibitors and Major Histocompatibility Class I Molecules
DownloadFall 2018
The leukocyte immunoglobulin-like receptor family (LILR) is composed of inhibitory and activating receptors that are widely expressed on immune cells and interact with classical and non-classical MHC-I. Recently, several ligands have been identified for the LILRs including the three...
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Characterization of Human Pancreatic Beta-cell Progenitors as a Means to Alleviate the Shortage of Donor Tissue for Islet Transplantation
DownloadFall 2012
The current shortage of islet tissue from cadaveric human donors is not sustainable and will preclude islet transplantation from becoming a widespread therapeutic treatment for those with type 1 diabetes. A potential alternative source of tissue may be through isolating, expanding, and...