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Skip to Search Results- 1Adam, Ibrahim S. Y.
- 1Akinwumi, Segun M
- 1Anderson, Sarah J
- 1Badr, Dina EFA
- 1Boulet, Joel L
- 1Chakraborty, Tathagata
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A novel mouse model of acute antibody-mediated transplant rejection shows simultaneous complement activating and anti-inflammatory effects of donor specific IgG antibodies
DownloadFall 2013
We developed a small animal model of pure antibody-mediated rejection (ABMR) by utilizing fully major histocompatibility complex (MHC) mismatched kidney allografts in mice. By examining resultant ABMR pathology, we show that terminal complement products C5a and C5b-9 are crucial in establishing...
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Fall 2020
Introduction: ABO-incompatible organ transplants (ABOi-Tx) recipients are at high-risk of rapid rejection mediated by ABO antibodies (ABO Abs). To manage and expand ABOi-Tx, it is necessary to understand the mechanism(s) by which natural and induced ABO Abs develop. Prior studies have used...
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An Exploration of the Cost of Liver Transplantation Using the OrganOx Normothermic Machine Perfusion in Comparison to Static Cold Storage in the Canadian Setting
DownloadFall 2021
Liver transplantation is life-saving but costly for the health care system, the patient and their caregivers. Over the last decade there has been a decrease in the available liver grafts leading to an increased use of extended criteria donors and an increase in the waitlist mortality rate. The...
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Fall 2014
Carbohydrate–protein interactions play key roles in a range of biological processes. Noticeable advancements have been made in understanding the features associated with the recognition of pyranosides (six-membered ring sugars) by proteins. In contrast, similar detailed studies about the...
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Characterization of Human Pancreatic Beta-cell Progenitors as a Means to Alleviate the Shortage of Donor Tissue for Islet Transplantation
DownloadFall 2012
The current shortage of islet tissue from cadaveric human donors is not sustainable and will preclude islet transplantation from becoming a widespread therapeutic treatment for those with type 1 diabetes. A potential alternative source of tissue may be through isolating, expanding, and...
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Spring 2015
Cytomegalovirus (CMV) is the most common opportunistic post-transplant infection. Although important advances have been made in the management and prevention of post-transplant CMV, current strategies for monitoring and prevention still show significant limitations. Such gaps create opportunities...
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Developing clinically translatable chimerism induction protocols in a stringent murine model
DownloadSpring 2020
Allogeneic hematopoietic chimerism induction via bone marrow transplantation (BMT) is thus far the most robust method for inducing donor antigen specific tolerance to allogeneic grafts. However, limited by the toxicity of the reagents used in conditioning the recipients, the demand of a high dose...
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Spring 2014
The development of rapid detection techniques to be applied at the point of use, has been gaining significant attention in the recent years. Rapid techniques are important and preferable methods in healthcare and environment sector due to the advantages they offer such as low-cost and reduced...
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Development of a Multisectorial Electroactive Nanowell Platform for Selective Single-Cell Sorting and Quantification
DownloadSpring 2022
The rapid isolation of specific rare target cells is of rising importance in current targeted patient treatment plans. Common cell sorting approaches such as stream-based dielectrophoresis (DEP) based cell sorters are limited by their spatial dimensions as only a number of cell types...
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Fall 2011
AC Dielectrophoresis, the motion of dielectric colloidal particles in the presence of an inhomogeneous AC electric field, has been utilized in this work as a mechanism for preventing channel wall fouling due to particle deposition for a multi-component colloidal system. Both attractive and...