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Skip to Search Results- 1Abu Alrub, Osama Y
- 1Agellon, Luis B.
- 1Berke, Sheldon S
- 1Chahal, Manik
- 1Chow, Ava Kalyca
- 1Clark, A.M.
- 21Graduate and Postdoctoral Studies (GPS), Faculty of
- 21Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 1Biochemistry, Department of
- 1Biochemistry, Department of/Journal Articles (Biochemistry)
- 1Toolkit for Grant Success
- 1Toolkit for Grant Success/Educational Materials (Toolkit for Grant Success)
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Fall 2016
Thrombotic microangiopathy (TMA) is a broad term for a range of diseases that usually manifest with rapid failure of the affected organ. Although different in etiology, these diseases share a common pattern of injury originating in the vascular endothelium. In turn, the injured vasculature...
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Manipulation of the Angiogenic Balance by Pharmacological Inhibition of Platelet PKC Signalling
DownloadFall 2012
Blood platelets mediate wound healing by preventing bleeding and by supporting growth of new blood vessels. Blood vessel growth is supported in part by growth factors released from platelet α-granules. Both platelet aggregation and α-granule release are mediated by intracellular signaling...
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Fall 2013
The placenta is an essential transitory fetal organ responsible for the key processes of nutrient, oxygen, and waste transfer between the mother and the fetus throughout gestation. Placental size is, importantly, known to correlate to fetal weight, and the malfunction and malformation of the...
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Novel Insights into the Role of O6-Methylguanine-DNA Methyltransferase in Glioblastoma Angiogenesis, Invasion, and Proliferation
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Glioblastoma multiforme (GBM) is characterized by aberrant angiogenesis, rapid proliferation, and widespread invasion through the brain parenchyma. Thus, the prognosis for these tumors remains extremely poor despite aggressive multimodal treatment including chemotherapy with the alkylating agent...
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Plasma Membrane Organization and Endocytosis of CD36 in Human Microvascular Endothelial Cells
DownloadSpring 2016
The plasma membrane is a dynamic lipid bilayer that surrounds the cell, embedded with different plasma membrane proteins, aiding communication between the inside and outside of the cells. Its functions are achieved through an intricate organization of lipid-lipid, lipid-protein and...
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2012
Radziwon-Balicka, A., Jurasz, P., Moncada de la Rosa, C.
Platelets, in addition to maintaining hemostasis, also stimulate angiogenesis by generating and releasing, upon activation, factors that promote the growth of new blood vessels. To date, at least 20 angiogenesis-regulating factors have been identified in platelets, including both promoters and...
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Spring 2011
Technological advances for treatment of congenital heart disease (CHD) have led to decreases in mortality over the past thirty years. Persistent morbidity into adolescence and adulthood necessitates regular medical follow-up and the influence of ongoing physical health issues on the teens...
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Fall 2012
The heart requires an uninterrupted supply of fuels to sustain its physiological function. Fatty acids are the predominant substrates and endogenous triglyceride turnover contributes significantly to fatty acid oxidation. Lipins are cytosolic, bifunctional enzymes involved in both glycerolipid...
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Fall 2014
Cardiac Fatty acids β-oxidation (FAO) markedly increases during maturation and become the major source of energy for the adult heart. However, excessive rates of FAO can compromise cardiac function in obesity, diabetes, and heart failure. Lysine acetylation has recently been identified as a...
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2002
Clark, A.M., MacIntyre, P.D., Sharp, C.
Access to health care should be determined by clinical need and not by age. Older people form an increasing proportion of the general population and of those with coronary heart disease, but compared with younger people they are less likely to be invited for cardiac rehabilitation programmes and...