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Skip to Search Results- 27Alzheimer's disease
- 15Hospitals
- 6Prevalence
- 5Dementia
- 3Amyloid precursor protein
- 3Cognitive impairment
- 25Graduate and Postdoctoral Studies (GPS), Faculty of
- 25Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 16Nursing, Faculty of
- 10Nursing, Faculty of/Chronicity
- 3Nursing, Faculty of/Health Systems
- 3Joel Martin Halpern Image Archive
- 25Thesis
- 14Article (Published)
- 4Image
- 2Review
- 1Article (Draft / Submitted)
- 1Conference/Workshop Poster
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Spring 2016
There is ample evidence that autophagy is affected in Alzheimer’s disease (AD) but the causes, the nature of the dysfunction and the mechanisms of autophagy impairment are unclear. Autophagy depends on vesicular trafficking and membrane fusion, events that rely on several protein complexes and...
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Fall 2020
Antihypertensives are prevalent in long-term care (LTC) populations, however the ratio of benefit to harm of antihypertensive treatment is unclear. There has not yet been a randomized controlled trial to examine the impact of deprescribing all classes of antihypertensive medication in the frail...
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Fall 2019
Alzheimer’s disease (AD) is characterized by the accumulation of amyloid beta (Aβ) peptide. It has been proposed that AD pathology is transmissible by a “prion-like” mechanism through extracellular vesicles (EVs) that contain Aβ. In this context, EVs describe both microvesicles and exosomes,...
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Cellular level/distribution of γ-secretase subunit nicastrin and its modulator p23 in the brain
DownloadSpring 2010
The processing of amyloid precursor protein (APP) by β- and γ-secretases produces amyloid β (Aβ) peptide, the principal component of the neuritic plaques found in Alzheimer’s disease (AD) pathology. The enzyme γ-secretase is a multimeric protein consisting of presenilins-1/2 (PS1/PS2), nicastrin,...
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Chart review of current end-of-life care needs and care practices in acute care hospitals: final report of an investigation
DownloadSpring 2011
A total of 1,018 charts of people who died from August 1, 2008 through July 31, 2009 were reviewed to describe and examine current end-of-life care needs and care practices provided in two acute care hospitals. The mean age of those who died was 72.5, the majority of decedents were elderly...
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Spring 2013
Alzheimer’s disease (AD) is a complex neurodegenerative disorder believed to be triggered by the accumulation of β-amyloid (Aβ)-related peptides derived from the proteolytic processing of amyloid precursor protein (APP). Research over the last two decades has shown that alterations in the levels...
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Data-Driven Approaches to Modeling Heterogeneity and Variability Across Asymptomatic Brain and Cognitive Aging, Mild Cognitive Impairment, and Alzheimer’s disease
DownloadSpring 2024
Objective We apply data-driven approaches to identify predictors of heterogeneous trajectories across normal aging, Mild Cognitive Impairment (MCI), and Alzheimer’s disease (AD). In Study 1, we investigated predictors of left and right hippocampal (HC) volume trajectory classes. In Study 2, we...