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Skip to Search Results- 69Graduate and Postdoctoral Studies (GPS), Faculty of
- 69Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
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- 13School of Public Health
- 12Nursing, Faculty of/Chronicity
- 9School of Public Health/Journal Articles (Public Health)
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Role of Glutamate and GABA in a mouse model expressing mutant human APP in the absence of NPC1 protein
DownloadSpring 2013
Cholesterol plays a critical role in Alzheimer’s disease (AD) pathogenesis, but the underlying mechanisms remain unclear. To address this issue we have generated a line of ANPC transgenic mice that overexpress mutant-human amyloid precursor protein in the absence of cholesterol transporting...
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Roles of the Insulin-like Growth Factor-II/Cation-independent Mannose 6-phosphate Receptor and Cathepsin D in Alzheimer’s Disease Pathology
DownloadSpring 2016
Alzheimer’s disease (AD) is the most common type of senile dementia affecting the elderly. A critical contributing factor to the neurodegeneration and development of AD pathology stems from the processing of amyloid precursor protein (APP), leading to the generation of β-amyloid (Aβ) peptides....
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2007
Virani, S. N., Schopflocher, D. P., Russell, M. L., Svenson, L.
Varicella vaccine was licensed in Canada in 1998, and a publicly funded vaccination programme introduced in the province of Alberta in 2001. In theory the vaccination programme might increase the burden of disease from shingles, making it important to develop baseline data against which future...
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Sensory Nerve Injuries: Advances in Diagnosis and Novel Therapy to Enhance Sensory Recovery in Humans
DownloadFall 2013
The unique difference between central and peripheral nervous systems is that regeneration actually occurs in the periphery. However, the functional recovery after surgical repair is highly variable and return to pre-injury state despite surgical advances is rare. When specifically looking at...
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Simultaneous temporal trends in dementia incidence and prevalence, 2005–2013: A population-based retrospective cohort study in Saskatchewan, Canada
Simultaneous temporal trends in dementia incidence and prevalence, 2005–2013: A population-based retrospective cohort study in Saskatchewan, Canada
Download2015-11-25
Forbes, D., Innes, A., Morgan, D. G., Quail, J. M., O'Connell, M. E., Teare, G. F., Kosteniuk, J. G., Stewart, N. J., Bello-Haas, V. D., Crossley, M., Kirk, A., Mou, H., McBain, L.
Background: Original studies published over the last decade regarding time trends in dementia report mixed results. The aims of the present study were to use linked administrative health data for the province of Saskatchewan for the period 2005/2006 to 2012/2013 to: (1) examine simultaneous...
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Fall 2020
Tauopathies are a class of neurological disorders associated with the aggregation of the tau protein into neurofibrillary tangles. The most prominent tauopathy is Alzheimer’s disease (AD), which presents as two forms: early onset (familial, fAD) and late onset (sporadic, sAD). sAD does not have a...
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Spring 2014
Modifiable cardiovascular disease (CVD) risk factors, such as adiposity, are already associated with atherosclerotic progression in childhood. Less is known about whether physical activity (PA) is associated with progression of atherosclerosis in non-clinical samples of children. This...
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2003
Schopflocher, D., Voaklander, D. C., Rowe, B. H., May, L. A., Saunders, L. D., Svenson, L. W., Dryden, D. M., Yiannakoulias, N.
Objectives: To describe the incidence and pattern of traumatic spinal cord injury and cauda equina injury (SCI) in a geographically defined region of Canada. Methods: The study period was April 1, 1997 to March 31, 2000. Data were gathered from three provincial sources: administrative data from...
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The Epidemiology of Venous Thromboembolism in Alberta, Canada: A Population Based Cohort Study.
DownloadSpring 2016
Background: Venous thromboembolism (VTE), comprises both deep vein thrombosis (DVT) and pulmonary embolism (PE). It is a common acute cardiovascular event associated with increased long-term morbidity, disability, all-cause mortality, and high rates of recurrence. Major advances in diagnosis,...