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- 27Alzheimer's disease
- 11Cognitive impairment
- 4Dementia
- 4Long-term care
- 3Amyloid precursor protein
- 35Graduate and Postdoctoral Studies (GPS), Faculty of
- 35Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 15Nursing, Faculty of
- 9Nursing, Faculty of/Chronicity
- 4Biological Sciences, Department of
- 4Biological Sciences, Department of/Journal Articles (Biological Sciences)
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Bioturbation and Resource Quality: A Case Study from the Upper Cretaceous Lysing and Nise Formations, Ellida and Midnatsoll Fields, Norwegian Sea
DownloadSpring 2013
Nine cores (approx. 156 m) within the Upper Cretaceous Lysing and Nise formations (Møre Basin, Norwegian continental shelf) are studied in order to assess the relationship between bioturbate fabric and the resulting permeability distribution. Overall, the Lysing and Nise formations strata...
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Cellular level/distribution of γ-secretase subunit nicastrin and its modulator p23 in the brain
DownloadSpring 2010
The processing of amyloid precursor protein (APP) by β- and γ-secretases produces amyloid β (Aβ) peptide, the principal component of the neuritic plaques found in Alzheimer’s disease (AD) pathology. The enzyme γ-secretase is a multimeric protein consisting of presenilins-1/2 (PS1/PS2), nicastrin,...
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Spring 2013
Alzheimer’s disease (AD) is a complex neurodegenerative disorder believed to be triggered by the accumulation of β-amyloid (Aβ)-related peptides derived from the proteolytic processing of amyloid precursor protein (APP). Research over the last two decades has shown that alterations in the levels...
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Coal Liquefaction Liquid Quality: Influence of Temperature and Heating Approach on Solvent Extraction of Coal
DownloadFall 2014
This project evaluated the impact of reaction temperature and of additional heating steps on the quality of the liquids obtained from solvent extraction of a lignite coal with tetralin. The points of focus were the coal liquid yield, physical properties, aromatic content and iron pyrite...
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Fall 2013
Background: Ischemic stroke is associated with cognitive impairment, but the acute cognitive sequelae of transient ischemic attack (TIA) and minor stroke is unknown. We hypothesized that transient cognitive impairment can be predicted by diffusion-weighted imaging (DWI) lesion volume. Methods:...
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Fall 2018
Amyotrophic Lateral Sclerosis (ALS) involves the progressive loss of upper and lower motor neurons. Frontotemporal lobar degeneration (FTLD) has been reported in a considerable proportion of patients, manifesting as cognitive and behavioural impairment in at least 25-50%, with 10-15% patients...
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Data-Driven Approaches to Modeling Heterogeneity and Variability Across Asymptomatic Brain and Cognitive Aging, Mild Cognitive Impairment, and Alzheimer’s disease
DownloadSpring 2024
Objective We apply data-driven approaches to identify predictors of heterogeneous trajectories across normal aging, Mild Cognitive Impairment (MCI), and Alzheimer’s disease (AD). In Study 1, we investigated predictors of left and right hippocampal (HC) volume trajectory classes. In Study 2, we...
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De novo genome sequence assembly of a filamentous fungus using Sanger, 454 and Illumina sequence data
Download2009-01-01
Docking, Roderick T., Mardis, Elaine, Hamelin, Richard C., Jones, Steven J. M., Marra, Marco A., Seidel, Michael, Chan, Simon K., Breuil, Colette, Liao, Nancy Y., Birol, Inanc, Robertson, Gordon, Holt, Robert A., Platt, Darren, Bohlmann, Jörg, DiGuistini, Scott, Hirst, Martin
Sequencing-by-synthesis technologies can reduce the cost of generating de novo genome assemblies. We report a method for assembling draft genome sequences of eukaryotic organisms that integrates sequence information from different sources, and demonstrate its effectiveness by assembling an...
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Defining Quality in Early Learning and Childcare among Visible Cultural Minority Families in Edmonton, Alberta
DownloadSpring 2023
Immigration is a key part of Canada’s strategy for population growth, and in recent years the number of visible minority immigrant families have seen a significant increase. However, they face significant settlement challenges that can lead to chronic poverty. For those with children, poverty can...