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Freshwater Sponges Have Functional, Sealing Epithelia with High Transepithelial Resistance and Negative Transepithelial Potential
Download2010
Leys, S.P., Goss, G.G., Adams, E.D.M.
Epithelial tissue — the sealed and polarized layer of cells that regulates transport of ions and solutes between the environment and the internal milieu — is a defining characteristic of the Eumetazoa. Sponges, the most ancient metazoan phylum [1], [2], are generally believed to lack true...
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Generation of a restriction minus enteropathogenic Escherichia coli E2348/69 strain that is efficiently transformed with large, low copy plasmids
Download2008
Raivio, T.L., Price, N.L., Ward, J.D., Hobson, N.
Background Many microbes possess restriction-modification systems that protect them from parasitic DNA molecules. Unfortunately, the presence of a restriction-modification system in a given microbe also hampers genetic analysis. Although plasmids can be successfully conjugated into the...
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Genome-wide analysis of the transcriptional response to porcine reproductive and respiratory syndrome virus infection at the maternal/fetal interface and in the fetus
Download2016
Ladinig, Andrea, Stothard, Paul, Bao, Hua, Hong, Linjun, Lunney, Joan K., Harding, John C. S., Wilkinson, Jamie M., Plastow, Graham S.
Background Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) infection of pregnant pigs can result in congenital infection and ultimately fetal death. Little is known about immune responses to infection at the maternal-fetal interface and in the fetus itself, or the molecular events...
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Genome-wide analysis of thetranscriptional response to porcinereproductive and respiratory syndromevirus infection at the maternal/fetalinterface and in the fetus
Download2016-01-01
Wilkinson, Jamie M., Bao, Hua, Ladinig, Andrea, Hong, Linjun, Stothard, Paul, Lunney, Joan K., Plastow, Graham S., Harding, John C. S.
Background:Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) infection of pregnant pigs can result incongenital infection and ultimately fetal death. Little is known about immune responses to infection at thematernal-fetal interface and in the fetus itself, or the molecular events...
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GERp95, a membrane-associated protein that belongs to a family of proteins involved in stem cell differentiation
Download1999
DiMattia, G.E., Hansen, D., Tahbaz, N., Hobman, T.C., Hendricks, L.C., Pilgrim, D., Cikaluk, D.E.
A panel of mAbs was elicited against intracellular membrane fractions from rat pancreas. One of the antibodies reacted with a 95-kDa protein that localizes primarily to the Golgi complex or the endoplasmic reticulum (ER), depending on cell type. The corresponding cDNA was cloned and sequenced and...
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Homology in comparative, molecular, and evolutionary developmental biology: The radiation of a concept
Download2003
The present paper analyzes the use and understanding of the homology concept across different biological disciplines. It is argued that in its history, the homology concept underwent a sort of adaptive radiation. Once it migrated from comparative anatomy into new biological fields, the homology...
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2007
Wang, W., Wang, H., Wong, G.K.S., Zheng, H., Clark, T., Zhang, G., Kang, L., Wang, J., Shi, J., Wang, X.
Background Insects constitute the vast majority of known species with their importance including biodiversity, agricultural, and human health concerns. It is likely that the successful adaptation of the Insecta clade depends on specific components in its proteome that give rise to specialized...
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Identification of a novel lipase gene mutated in lpd mice with hypertriglyceridemia and associated with dyslipidemia in humans
Download2003-05-13
Wen, Xiao-Yan, Hegele, Robert A., Wang, Jian, Wang, Ding Yan, Cheung, Joseph, Wilson, Michael, Yahyapour, Maryam, Bai, Yahong, Zhuang, Lihua, Skaug, Jennifer, Young, T. Kue, Connelly, Philip W., Koop, Ben F., Tsui, Lap-Chee, Stewart, A. Keith
"Triglyceride (TG) metabolism is crucial for whole body and local energy homeostasis and accumulating evidence suggests an independent association between plasma TG concentration and increased atherosclerosis risk. We previously generated a mouse insertional mutation lpd (lipid defect) whose...
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IN HOT WATER: A BACTERIAL PATHOGEN DISPLAYING TEMPERATURE-ENHANCED VIRULENCE OF THE MICROALGA EMILIANIA HUXLEYI
DownloadFall 2016
Emiliania huxleyi is a globally abundant microalga that plays a significant role in biogeochemical cycles. Over the next century, sea surface temperatures are predicted to increase drastically, which will likely have significant effects on the survival and ecology of E. huxleyi. In a warming...