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Skip to Search Results- 1Badr, Dina EFA
- 1Hou, Shangmei
- 1Masoud, Andrew G.
- 1Reid, Colleen R.
- 1Stanislaus Alphonse, Anthuvan Rajesh
- 1Urbanowski, Matthew D.
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Fall 2017
Flaviviruses are important human pathogens that have an enormous impact on global health. Examples that have been studied in my research include dengue virus (DENV), West Nile virus (WNV) and most recently, Zika virus (ZIKV). Currently, there are very few vaccines against or therapeutic...
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Spring 2014
The introduction of WNV into North America in 1999 was followed by rapid spread throughout the continent. Today, WNV is an endemic pathogen in the west, with thousands of cases of severe infection reported annually. In addition to traditional vaccine research, there is an urgent need to...
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Fall 2022
Heart transplantation (HTx) is a life-saving intervention for patients with end-stage heart failure. Nonetheless, the development of Chronic Allograft Vasculopathy (CAV) limits the longevity of transplanted cardiac allografts and the survival of recipients. The pathogenesis of CAV begins with a...
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Epithelial and vascular progenitors in the developing lung: Newer insights and therapeutic implications
DownloadFall 2012
Stanislaus Alphonse, Anthuvan Rajesh
Bronchopulmonary dysplasia (BPD) and congenital diaphragmatic hernia (CDH) are life-threatening lung diseases affecting newborn infants. Both diseases are characterized by impaired lung development and are currently untreatable. Dysregulation in the number or function of lung progenitor cells is...
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Spring 2016
Flaviviruses, such as West Nile virus (WNV), Powassan virus (POW), and Saint Louis encephalitis virus (SLEV), are significant pathogens capable of causing serious neurological disease in both humans and animals. Despite their relevance to human health, treatment and vaccines for these viruses...
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Herpes Simplex Virus Requires VP11/12 to Activate Src Family Kinase-PI3 Kinase-Akt Signalling
DownloadFall 2010
This thesis defines a novel role for the Herpes Simplex Virus (HSV) tegument protein, virion protein (VP) 11/12 as a modulator of host cell signalling. Studies aimed at examining infection induced lymphocyte inactivation, revealed that VP11/12 is tyrosine phosphorylated in three lymphocyte...
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Fall 2017
The two types of rejection identified in the Banff histopathologic diagnosis are T cell-mediated rejection (TCMR) and antibody-mediated rejection (ABMR). TCMR is most common early post-transplant while ABMR is the main cause of late graft loss. Kidney transplant TCMR is diagnosed histologically...
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T cell-mediated inflammation is stereotyped: mouse delayed-type hypersensitivity reaction and mouse T cell-mediated rejection of renal allografts share common molecular mechanismsT cell-mediated inflammation is stereotyped
DownloadFall 2011
Genome-wide gene expression analysis of diseases has revealed large-scale changes in the expression of thousands of genes (transcripts) representing biological processes. The processes that occur during T cell-mediated rejection (TCMR) of renal allografts in mice and humans have been previously...