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Skip to Search Results- 25Aging
- 7Sex differences
- 6Vasoconstriction
- 3Sympathetic nervous system
- 2Amygdala subnuclei
- 2Blood pressure
- 1Abdualla, Radya Y
- 1Aghamohammadi Sereshki, Arash
- 1Alaazi, Dominic A
- 1Bartlett, Nathan T
- 1Bhullar, Khushwant Singh
- 1Caballero, Hebert S
- 6Department of Psychology
- 4Physical Education and Recreation
- 3Centre for Neuroscience
- 3Neuroscience
- 2Department of Biochemistry
- 2Department of Medicine
- 3Dixon, Roger (Psychology)
- 2Cummine, Jacqueline (Communication Sciences and Disorders)
- 1Ben Zvi, Ehud (History & Classics)
- 1Boliek, Carol (Communication Sciences and Disorders)
- 1Brown, Norman R. (Psychology)
- 1Darren DeLorey, PhD Faculty of Physical Education and Recreation; Rehabilitation Medicine
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Effect of dietary nitrate on sympathetic vasoconstriction in resting and contracting skeletal muscle
DownloadFall 2015
Dietary nitrate (NO3-) may increase nitric oxide (NO) bioavailability and alter the control of blood flow at rest and during exercise. This thesis investigated the effect of dietary NO3- supplementation on sympathetic mediated control of skeletal muscle blood flow in resting and contracting...
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Fall 2021
Chronological aging is one of the greatest risk factors of tauopathies, yet our understanding about the underlying molecular mechanism is limited. Studying physiological aging often requires an extended timeline and thus presents a significant hurdle for modeling late-onset disorders. In this...
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Effects of Tripeptide IRW (Ile-Arg-Trp) on metabolism, mitochondrial biogenesis, and lifespan extension
DownloadSpring 2022
Bioactive tripeptide IRW (Ile-Arg-Trp) was initially identified as an ACE (angiotensin-converting enzyme) inhibitory peptide from egg protein ovotransferrin. The pharmacological spectrum of IRW extends towards metabolic boosting and anti-diabetic properties as well. The overall objectives of this...
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Exploring barriers and facilitators to the implementation of healthy aging policy in suburban planning and transportation departments
DownloadSpring 2011
Purpose: The purpose of this research was examine potential barriers and facilitators to the implementation of healthy public policy related to aging, specifically in municipal planning and transportation departments, in the suburban context. Research Questions: What are the factors which...
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Insulin signaling, mitochondrial DNA copy number regulation and aging in Caenorhabditis elegans
DownloadFall 2010
Mitochondrial dysfunction is considered as a key mechanism of aging but little is known about the impact of mitochondrial biogenesis. Mitochondrial DNA (mtDNA) copy number control is an important aspect of mitochondrial biogenesis and is highly regulated in eukaryotic organisms. By studying mtDNA...
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Integrating Characteristics of Executive Functions in Non-Demented Aging: Structure, Trajectories, Classification, and Biomarker Predictors
DownloadSpring 2019
In aging, executive function (EF) performance (level) and change (trajectory) are linked to multiple interacting risk factors. Structurally, EFs have previously been represented as either a unitary (e.g., unidimensional) or diverse (e.g., multidimensional) set of abilities that change across the...
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Investigating Human Brain Function and Human Brain Organization Using Functional Magnetic Resonance Imaging at 4.7 T
DownloadFall 2020
Understanding the brain-cognition association has been a major goal of neuroscientists for more than 50 years. The discovery of functional magnetic resonance imaging (fMRI) blood-oxygen-level-dependent (BOLD) contrast by Ogawa and colleagues (1990, 1992) has fundamentally transformed the field of...
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Investigating the Effects of N2-Acetylphenelzine in the Sexes in Experimental Autoimmune Encephalomyelitis
DownloadFall 2017
Chronic pain is a highly prevalent symptom in Multiple Sclerosis (MS) and affects approximately half of patients at some stage of the disease. MS affects women more frequently than men and neuropathic pain is also reported as more severe, and frequent, in females with the disease. The underlying...
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Fall 2012
Ischemic heart disease remains a major cause of illness, disability and death worldwide, as such there remains a need for novel pharmacological agents that protect against myocardial ischemia reperfusion (I/R) injury. Epoxyeicosatrienoic acids (EETs) are cytochrome P450 (CYP) epoxygenase...
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Fall 2016
Background. Context use in sentence comprehension is fairly resistant to age-related cognitive decline; however, event-related potentials (ERPs) studies have shown age effects in neural activity associated with sentence comprehension, specifically when contextual information is manipulated. One...