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Spring 2011
This thesis explores the capabilities of cationic polymers modified with lipids of different carbon chain length to deliver DNA molecules to primary cells and transformed cell lines. Our studies focus on two different polymers: polyethylenimine (PEI) and poly(L-lysine) (PLL). Firstly, PEI and PLL...
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Improving Measurements of the Mixing State and Mass Concentration of Particulate Emissions from Aircraft Engines
DownloadSpring 2016
This research is focused towards improving techniques used to measure particulate emissions from aircraft engines, on two fronts: first, to characterize and quantify the mixing state of particulate emissions; and second, to calibrate black carbon mass instruments with a traceable mass...
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Spring 2014
Gene delivery is an emerging therapy for treatment of many different diseases and conditions, with the first therapy recently approved for clinical use. This thesis investigates non-viral carriers for gene delivery for bone regeneration, with an emphasis on the mechanisms of plasmid DNA (pDNA)...
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Intestinal Uptake of Barley Protein Nanoparticles as Delivery Vehicles for Bioactive Compounds
DownloadFall 2013
The use of nanoparticles as nutrient delivery vehicles enables the enhancement of the oral bioavailability and health promoting benefits of bioactive compounds. Barley protein nanoparticles were developed in previous study for hydrophobic compound delivery. The objective of the present study was...
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Introduction of Competition in Regulated Markets: Analysis of Colombia’s Natural Gas Industry
DownloadFall 2016
This dissertation deals with the introduction of competition in regulated industries such as natural gas. The thesis focuses on the recently developed Colombian natural gas market and uses a more mature market, the deregulated gas market existing in the province of Alberta, Canada, as a benchmark...
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Investigation of Barley Proteins’ Interfacial Properties and Their Applications as Nanoscaled Materials
DownloadSpring 2016
The overall objective of this thesis research is to gain fundamental knowledge on the relationship between barley protein molecular structures and their interfacial properties as well as to develop barley protein value-added applications with special emphasis on their utilization as nanoparticles...
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Spring 2019
Synthetic oligodeoxynucleotides containing unmethylated CpG motifs (CpG ODNs) are powerful stimulators of innate and adaptive immune responses, exerting their activity through the interaction with endolysosomal Toll-like receptor 9 (TLR9) expressed by antigen presenting cells (APCs). The strong...
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Mimicking the Behaviors of Oil Contaminated Clays Using Functionalized Silica Nanoparticles
DownloadSpring 2018
Fine sand and clay particles arise naturally in diverse industrial and environmental remediation contexts. Organic compounds for example from oil production or oil spills can adsorb on their surface and influence their oil water interfacial behaviors. To isolate the impact of contamination and...
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Modulation of the uptake and toxicity of PFOA by Polystyrene and Titanium dioxide nanoparticles in Pacific oysters (Magallana gigas) and Daphnia (Daphnia magna)
DownloadFall 2023
Nanomaterial toxicity is a major concern in today’s world. The benefits of nanoparticle use have led to the production of various kinds of nanomaterials including a high volume of nanoplastics, TiO2 nanoparticles, and CeO nanoparticles. Different nanomaterials are shown to be a suitable vector...
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Fall 2016
Macrophages are the primary cells of innate immunity that provide the first line of defence against any external stimuli. Their phagocytic properties enable them to engulf invading microbes or foreign particles. The phagocytic capability of macrophages plays a major role in interfering with drug...