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Skip to Search Results- 4DNA Damage
- 2Advanced Glycation End Products
- 2Isoferulic Acid
- 1Absorption Spectroscopy
- 1Anticancer Agents
- 1Antiviral Agents
- 3Loppnow, Glen R.
- 2Adisakwattana, Sirichai
- 2Chan, Catherine B.
- 2El-Yazbi, Amira F.
- 2Meeprom, Aramsri
- 2Sompong, Weerachat
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2014-01-01
El-Yazbi, Amira F., Loppnow, Glen R.
Nucleic acids (NAs) play a vital role in numerous biological processes. Absorption of ultraviolet (UV) light by NAs can result in DNA damage at the molecular level, leading to mutagenesis, carcinogenesis, and cell death. Thus, much effort has been focused on developing methods for detecting...
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Isoferulic acid prevents methylglyoxal-induced protein glycation and DNA damage by free radical scavenging activity
Download2015
Sompong, Weerachat, Suantawee, Tanyawan, Thilavech, Thavaree, Adisakwattana, Sirichai, Meeprom, Aramsri, Chan, Catherine B.
Background Isoferulic acid (IFA), a naturally occurring cinnamic acid derivative, is a main active ingredient of the rhizoma of Cimicifuga dahurica. It has been shown various pharmacological activities. The aim of the study was to investigate the effect of IFA against MG-induced protein glycation...
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Isoferulic acid, a new anti-glycation agent, inhibits fructose- and glucose-mediated protein glycation in vitro
Download2013
Meeprom, Aramsri, Adisakwattana, Sirichai, Sompong, Weerachat, Chan, Catherine B.
The inhibitory activity of isoferulic acid (IFA) on fructose- and glucose-mediated protein glycation and oxidation of bovine serum albumin (BSA) was investigated. Our data showed that IFA (1.25–5 mM) inhibited the formation of fluorescent advanced glycation end products (AGEs) and non-fluorescent...
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2013-01-01
Nair, Sindhu G., Loppnow, Glen R.
The exposure of DNA to ultraviolet (UV) radiation causes sequence‐dependent damage. Thus, there is a need for an analytical technique that can detect damage in large numbers of DNA sequences simultaneously. In this study, we have designed an assay for UVC‐induced DNA damage in multiple...
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2018-01-01
El-Yazbi, Amira F., Loppnow, Glen R.
Hepatocellular carcinoma is one of the most common malignant tumors in the world. Chronic hepatitis B and C infections are the most common etiologies of hepatocellular carcinoma worldwide. In this study, we explore the potential DNA damaging effect of some FDA-approved antiviral drugs which may...