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Skip to Search Results- 1Al Onazi, Mona Moraybed
- 1Alyenbaawi, Hadeel Eb
- 1Barber, Quinn
- 1Bernier, Ashlyn
- 1Champion, Claudine C.
- 1Chaurasiya, Shyambabu
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Fall 2011
Breast cancer is the second leading cause of cancer death in Canadian women. In these patients, mortality is due to metastasis of cancer cells from the breast to distant organs, resulting in impairment of function. To metastasize, cells must move through the stroma of the breast, enter the...
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Novel Agents Inhibiting Hepatitis C Virus; Application to Prevention of Re-infection after Liver Transplantation
DownloadFall 2013
Recurrent Hepatitis C virus infection drives inferior outcomes experienced by patients undergoing liver transplantation due to HCV-associated liver disease. Existing therapies exhibit increased toxicity, poor efficacy, and profound patient intolerability in the immediate transplantation period....
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Spring 2017
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), continues to be a leading infectious cause of death worldwide with approximately 10 million new cases and 2 million deaths attributed annually. There has been resurgence in active TB infections since 1980s and the World Health...
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Profiling and Identification of Small Non-coding RNAs as Prognostic Markers for Breast Cancer
DownloadFall 2016
Breast cancer (BC) continues to be one of the leading causes of cancer related death among women. Despite continuous progress in screening, diagnosis and treatment of BC, a subset of patients experience recurrence and/or death. Optimal management of BC has remained a challenge due to these...
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Quantitative and Qualitative Content Analysis of Breast Cancer, Heart Disease, and Stroke Media Messages from Local Canadian Media
DownloadFall 2014
This study examined media coverage of breast cancer (N=145) and heart disease and stroke (N=39) news articles, videos, advertisements, and images in a local Canadian context through quantitative and thematic content analyses. Statistical analysis (Cramer’s V) revealed significant differences in...
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Regulation of collagen type I production by ionizing radiation and transforming growth factor-β1 in primary human skin fibroblasts derived from early stage breast cancer patients in relation to acute radiation-induced toxicity
DownloadFall 2011
Regulation of collagen type I (CI) in fibroblasts is critical for the onset and development of skin toxicities induced by radiation therapy (RT). Transforming growth factor beta-1 (TGF-β1) and vascular endothelial growth factor (VEGF) promote CI synthesis, while its degradation is modulated by...
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Restoring Body Image after Breast Cancer through Exercise and Art Sculpture “RISE UP” after Breast Cancer: A Pilot Multi-Methods Study
DownloadFall 2020
The purpose of this thesis was to explore and describe body image in survivors of breast cancer in the context of supportive care, with specific focus on resistance exercise training and art therapy. The overall purpose of this work was to inform current practice and offer an alternative approach...
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Safe Polymeric Nucleic Acid Delivery Systems for Cancer Therapy: Focus on Breast Cancer and Chronic Myeloid Leukemia
DownloadFall 2021
Meenakshi Sundaram, Daniel Nisakar
RNA interference (RNAi) is a promising technology to specifically target the upregulated genes that provide uncontrolled proliferation and survival of cancers. The target specific silencing is accomplished by the delivery of small interfering RNA (siRNA), which require safe delivery systems to...
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Fall 2018
Protein kinases are critical players in cell signaling processes and their activity leads to the phosphorylation of substrates, often regulating enzymatic activity. 518 protein kinases are encoded in the human genome, however, there are many features within the catalytic domain of these proteins...
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Synthesis and Characterization of Novel Radiolabelled Substrates for Imaging of GLUT5 Expression in Human Breast Cancer Using Positron Emission Tomography
DownloadFall 2012
Overactive glucose transport and metabolism has been widely recognized as one of the fundamental hallmarks of cancer and its progression. The facilitative glucose transporter GLUT1 is widely overexpressed in many tumor types compared to their untransformed counterparts. Due to this, the glucose...