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Skip to Search Results- 1Anderson, Sarah J
- 1Badejo, Ifueko
- 1Barlott, Timothy
- 1Beggs, Megan R
- 1Campbell, Elizabeth J
- 1Carey, Shane F
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Characterization of Human Pancreatic Beta-cell Progenitors as a Means to Alleviate the Shortage of Donor Tissue for Islet Transplantation
DownloadFall 2012
The current shortage of islet tissue from cadaveric human donors is not sustainable and will preclude islet transplantation from becoming a widespread therapeutic treatment for those with type 1 diabetes. A potential alternative source of tissue may be through isolating, expanding, and...
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Characterizing the role of the endocannabinoid system’s catabolic enzymes FAAH and MAGL in the development of functional sensorimotor activities in zebrafish
DownloadFall 2022
The endocannabinoid system (eCS) plays a critical role in a variety of homeostatic and developmental processes. Generally, the eCS relies on the naturally produced compounds known as endocannabinoids (eCBs), which are lipophilic signaling molecules that interact with cannabinoid receptors to...
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Conserving cougars in a rural landscape: habitat requirements and local tolerance in west-central Alberta
DownloadSpring 2011
Maintaining large carnivores in human-dominated landscapes poses a significant conservation challenge. Extirpation is common because of habitat loss or direct persecution. I studied cougar habitat selection and human perception of cougars in west-central Alberta to better understand...
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Creating and Capitalizing on Opportunities to Reduce Poverty: The Process and Power of Integrated Knowledge Translation
DownloadSpring 2016
This thesis describes the experiences of partners involved in integrated knowledge translation (iKT)—a poorly understood process wherein partners from diverse professional spheres (e.g. community, government, and academia) work together to ensure research generated is relevant for the context of...
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DHR51 as a coordinator of heme biosynthesis and steroid hormone production to time metamorphosis in Drosophila melanogaster
DownloadFall 2019
Development from a juvenile to an adult animal is driven by pulses of steroid hormones released at precise developmental times. Inputs from the environment, timing cues, and nutritional factors are all coordinated to produce a steroid hormone pulse. Insects and in particular, the fruit fly...
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Delineation of molecular mechanisms of intestinal calcium absorption during postnatal development
DownloadFall 2021
Infants and children must maintain a positive calcium balance for appropriate growth. Evidence suggests that adaptations in intestinal absorption of calcium are the major determinant of this net balance. However, the molecular details of the pathways mediating this increased absorption at a young...
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Development and Evolution of Complex Reproductive Traits in the Brassicaceae and Cleomaceae
DownloadSpring 2023
Flowering plants exhibit a bewildering diversity of forms, which raises fundamental questions on how that diversity arises. A cornerstone of evolutionary developmental biology is the expansion of comparative landscapes and establishment of focal clades that enable investigation of complex and...
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Fall 2023
Motoneuron properties and their firing patterns undergo significant changes throughout development and in response to neuromodulators like serotonin. In this thesis we examined intrinsic motoneuron properties in 50 typically developing participants ranging in age from 7 to 53 years. The primary...