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Characterizing the role of the endocannabinoid system’s catabolic enzymes FAAH and MAGL in the development of functional sensorimotor activities in zebrafish
DownloadFall 2022
The endocannabinoid system (eCS) plays a critical role in a variety of homeostatic and developmental processes. Generally, the eCS relies on the naturally produced compounds known as endocannabinoids (eCBs), which are lipophilic signaling molecules that interact with cannabinoid receptors to...
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Fall 2009
Aroonassala Patten, Shunmoogum
Glutamate AMPA receptors (AMPARs) are major excitatory receptors in the vertebrate CNS. In many biological systems there are changes in the properties of AMPARs during development that are essential for providing an increase in efficiency of information transfer between neurons and a refinement...
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Retinoic acid prevents alteration of neuronal morphology and locomotion of zebrafish embryos induced by ethanol exposure during gastrulation
DownloadFall 2018
Ethanol (EtOH) exposure during development has been shown to lead to deficits in fine and gross motor control. In this study I used zebrafish embryos in the gastrulation stage to determine the developmental effects of a brief, 5-hour exposure to EtOH. I treated fertilized zebrafish eggs from 5.25...
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The Expression of Transmembrane AMPA Receptor Regulatory Proteins (TARPs) in Developing Zebrafish (Danio rerio)
DownloadFall 2013
In embryonic vertebrates, newly-formed synapses are quiet until they are unsilenced through a process that resembles synaptic plasticity but remains mechanistically unclear. I used gene expression to determine if Transmembrane AMPA Receptor Regulatory Proteins (TARPs), AMPA receptor auxiliary...
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Spring 2012
The escape response in zebrafish is mediated in part by the Mauthner cell and its two homologues, MiD2cm and MiD3cm. In adult fish, the Mauthner cell fires a single action potential when activated while the homologues fire multiple action potentials. Their distinct firing properties are partially...